PuSH - Publikationsserver des Helmholtz Zentrums München

Asgharsharghi, A. ; Tian, W. ; Haehnel-Taguchi, M.* ; López-Schier, H.

Sarm1 is dispensable for mechanosensory-motor transformations in zebrafish.

MicroPubl. Biol. 2021, DOI: 10.17912/micropub.biology.000369 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Sarm1 is an evolutionary conserved protein that is essential for Wallerian axon degeneration. Sarm1 has emerged as a therapeutic target to treat neuropathies derived from metabolic or chemical stress and physical injury of axons. Yet, the full repertoire of consequences of inhibiting Sarm1 remains unknown. Here we show that loss of Sarm1 in zebrafish does not affect the sensorimotor transformations that underlie rheotaxis. In addition, Sarm1 deficit accelerates the re-growth of regenerating axons. These data indicate that systemic inhibition of Sarm1 is a viable therapeutic option compatible with sustained nervous system function.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 2578-9430
e-ISSN 2578-9430
Zeitschrift microPublication biology
Quellenangaben Band: 2021 Heft: , Seiten: , Artikelnummer: , Supplement: ,
Verlagsort Pasadena, CA
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Sensory Biology and Organogenesis (SBO)