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Liu, N. ; O'Connor, P. ; Gujrati, V. ; Gorpas, D. ; Glasl, S. ; Blutke, A. ; Walch, A.K. ; Kleigrewe, K.* ; Sattler, M. ; Plettenburg, O. ; Ntziachristos, V.

Facile synthesis of a croconaine-based nanoformulation for optoacoustic imaging and photothermal therapy.

Adv. Healthc. Mater. 10:e2002115 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Near-infrared (NIR) light absorbing theranostic agents can integrate optoacoustic imaging and photothermal therapy for effective personalized precision medicine. However, most of these agents face the challenges of unstable optical properties, material-associated toxicity, and nonbiodegradability, all of which limit their biomedical application. Several croconaine-based organic agents able to overcome some of these limitations have been recently reported, but these suffer from complicated multistep synthesis protocols. Herein, the use of CR760, a croconaine dye with excellent optical properties, is reported for nanoparticle formulation and subsequent optoacoustic imaging and photothermal therapy. Importantly, CR760 can be conveniently prepared in a single step from commercially available materials. Furthermore, CR760 can be covalently attached, via a polyethylene glycol linker, to the αvβ3 integrin ligand c(RGDyC), resulting in self-assembled nanoparticles (NPs) with cancer-targeting capability. Such CR760RGD-NPs exhibit strong NIR absorption, high photostability, high optoacoustic generation efficiency, and active tumor-targeting, making them ideal candidates for optoacoustic imaging. Due to favorable electron transfer, CR760RGD-NPs display a 45.37% photothermal conversion efficiency thereby rendering them additionally useful for photothermal therapy. Targeted tumor elimination, biosafety, and biocompatibility are demonstrated in a 4T1 murine breast tumor model. This work points to the use of CR760RGD-NPs as a promising nanoagent for NIR-based cancer phototheranostics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Croconaine ; Nanoparticles ; Optoacoustics ; Photothermal Therapy
ISSN (print) / ISBN 2192-2640
e-ISSN 2192-2659
Zeitschrift Advanced healthcare materials
Quellenangaben Band: 10, Heft: 9, Seiten: , Artikelnummer: e2002115 Supplement: ,
Verlag Wiley
Verlagsort Weinheim
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Institute of Experimental Genetics (IEG)
Research Unit Analytical Pathology (AAP)
Institute of Structural Biology (STB)
Institute of Medicinal Chemistry (IMC)
Förderungen China Scholarship Council (CSC)
Bundesministerium fur Bildung und Forschung (BMBF)
Deutsche Forschungsgemeinschaft
EC | European Research Council (ERC)
German Mouse Clinic/Institute of Experimental Genetics
Technische Universität München
EU Horizon 2020
Helmholtz Association
Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München