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Sampath, V.* ; Rabinowitz, G.* ; Shah, M.* ; Jain, S.* ; Diamant, Z.* ; Jesenak, M.* ; Rabin, R.* ; Vieths, S.* ; Agache, I.* ; Akdis, M.* ; Barber, D.* ; Breiteneder, H.* ; Chinthrajah, S.* ; Chivato, T.* ; Collins, W.* ; Eiwegger, T.* ; Fast, K.* ; Fokkens, W.* ; O'Hehir, R.E.* ; Ollert, M.* ; O'Mahony, L.* ; Palomares, O.* ; Pfaar, O.* ; Riggioni, C.* ; Shamji, M.H.* ; Sokolowska, M.* ; Torres, M.J.* ; Traidl-Hoffmann, C. ; van Zelm, M.* ; Wang, Y.* ; Zhang, L.* ; Akdis, C.* ; Nadeau, K.C.*

Vaccines and Allergic reactions: The past, the current COVID-19 pandemic, and future perspectives.

Allergy 76, 1640-1660 (2021)
Verlagsversion Postprint DOI PMC
Open Access Green
Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur aftervaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Covid-19 ; Sars-cov-2 ; Allergy ; Anaphylaxis ; Vaccine; Protein-coupled Receptor-x2; Anti-peg Antibodies; Mast-cell; Hypersensitivity Reactions; Adverse-reactions; Safety Data; Anaphylaxis; Vaccination; Children; Gelatin
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 76, Heft: 6, Seiten: 1640-1660 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Environmental Medicine (IEM)
Förderungen NIAID SARS Vaccine study
Crown Foundation
Sunshine foundation
Parker foundation