PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Appelman, M.D.* ; Wettengel, J.M. ; Protzer, U. ; Oude Elferink, R.P.J.* ; van de Graaf, S.F.J.*

Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP.

Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1866:158960 (2021)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes, mediates the uptake of conjugated bile acids. In conditions where bile flow is impaired (cholestasis), pharmacological inhibition of NTCP-mediated bile acid influx is suggested to reduce hepatocellular damage due to bile acid overload. Furthermore, NTCP has been shown to play an important role in hepatitis B virus (HBV) and hepatitis Delta virus (HDV) infection by functioning as receptor for viral entry into hepatocytes. This review provides a summary of current molecular insight into the regulation of NTCP expression at the plasma membrane, hepatic bile acid transport, and NTCP-mediated viral infection.
Impact Factor
Scopus SNIP
Altmetric
4.698
1.302
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Asbt ; Bsep ; Cholestasis ; Hbv ; Hdv; Taurocholate Cotransporting Polypeptide; B-virus Infection; Organic Anion Transporters; Na+/taurocholate Cotransport; Dependent Translocation; Nuclear Receptor; Rat Ntcp; Expression; Inhibition; Mouse
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 1388-1981
Zeitschrift Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Quellenangaben Band: 1866, Heft: 8, Seiten: , Artikelnummer: 158960 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-502700-003
Förderungen Amsterdam University Medical Centers (AUMC)
Dioraphte Foundation
Dutch Cancer Foundation (KWF)
German Research Foundation (DFG)
Amsterdam University Medical Centers (AGEM innovation grant)
DOI 10.1016/j.bbalip.2021.158960
WOS ID WOS:000656122900014
Scopus ID 85105361214
PubMed ID 33932583
Erfassungsdatum 2021-06-15
[➜Korrektur melden]