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Appelman, M.D.* ; Wettengel, J.M. ; Protzer, U. ; Oude Elferink, R.P.J.* ; van de Graaf, S.F.J.*

Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP.

Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1866:158960 (2021)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes, mediates the uptake of conjugated bile acids. In conditions where bile flow is impaired (cholestasis), pharmacological inhibition of NTCP-mediated bile acid influx is suggested to reduce hepatocellular damage due to bile acid overload. Furthermore, NTCP has been shown to play an important role in hepatitis B virus (HBV) and hepatitis Delta virus (HDV) infection by functioning as receptor for viral entry into hepatocytes. This review provides a summary of current molecular insight into the regulation of NTCP expression at the plasma membrane, hepatic bile acid transport, and NTCP-mediated viral infection.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Asbt ; Bsep ; Cholestasis ; Hbv ; Hdv; Taurocholate Cotransporting Polypeptide; B-virus Infection; Organic Anion Transporters; Na+/taurocholate Cotransport; Dependent Translocation; Nuclear Receptor; Rat Ntcp; Expression; Inhibition; Mouse
ISSN (print) / ISBN 1388-1981
Zeitschrift Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Quellenangaben Band: 1866, Heft: 8, Seiten: , Artikelnummer: 158960 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
Förderungen Amsterdam University Medical Centers (AUMC)
Dioraphte Foundation
Dutch Cancer Foundation (KWF)
German Research Foundation (DFG)
Amsterdam University Medical Centers (AGEM innovation grant)