PuSH - Publikationsserver des Helmholtz Zentrums München: Genetic predictors of fibrin D-dimer levels in healthy adults.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Smith, N.L.* ; Huffman, J.E.* ; Strachan, D.P.* ; Huang, J.* ; Dehghan, A.* ; Trompet, S.* ; Lopez, L.M.* ; Shin, S.Y.* ; Baumert, J.J. ; Vitart, V.* ; Bis, J.C.* ; Wild, S.H.* ; Rumley, A.* ; Yang, Q.* ; Uitterlinden, A.G.* ; Stott, D.J.* ; Davies, G.* ; Carter, A.M.* ; Thorand, B. ; Polasek, O.* ; McKnight, B.* ; Campbell, H.* ; Rudnicka, A.R.* ; Chen, M.H.* ; Buckley, B.M.* ; Harris, S.E.* ; Peters, A. ; Pulanic, D.* ; Lumley, T.* ; de, Craen, A.J.* ; Liewald, D.C.* ; Gieger, C. ; Campbell, S.* ; Ford, I.* ; Gow, A.J.* ; Luciano, M.* ; Porteous, D.J.* ; Guo, X.* ; Sattar, N.* ; Tenesa, A.* ; Cushman, M.* ; Slagboom, P.E.* ; Visscher, P.M.* ; Spector, T.D.* ; Illig, T.* ; Rudan, I.* ; Bovill, E.G.* ; Wright, A.F.* ; McArdle, W.L.* ; Tofler, G.* ; Hofman, A.* ; Westendorp, R.G.* ; Starr, J.M.* ; Grant, P.J.* ; Karakas, M.* ; Hastie, N.D.* ; Psaty, B.M.* ; Wilson, J.F.* ; Lowe, G.D.* ; O'Donnell, C.J.* ; Witteman, J.C.* ; Jukema, J.W.* ; Deary, I.J.* ; Soranzo, N.* ; Koenig, W.* ; Hayward, C.

Genetic predictors of fibrin D-dimer levels in healthy adults.

Circulation 123, 1864-1872 (2011)

Verlagsversion

DOI

PMC

	Closed

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

BACKGROUND: Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. METHODS AND RESULTS: A genome-wide investigation of the genomic correlates of plasma D-dimer levels was conducted among 21 052 European-ancestry adults. Plasma levels of D-dimer were measured independently in each of 13 cohorts. Each study analyzed the association between ≈2.6 million genotyped and imputed variants across the 22 autosomal chromosomes and natural-log–transformed D-dimer levels using linear regression in additive genetic models adjusted for age and sex. Among all variants, 74 exceeded the genome-wide significance threshold and marked 3 regions. At 1p22, rs12029080 (P=6.4×10(-52)) was 46.0 kb upstream from F3, coagulation factor III (tissue factor). At 1q24, rs6687813 (P=2.4×10(-14)) was 79.7 kb downstream of F5, coagulation factor V. At 4q32, rs13109457 (P=2.9×10(-18)) was located between 2 fibrinogen genes: 10.4 kb downstream from FGG and 3.0 kb upstream from FGA. Variants were associated with a 0.099-, 0.096-, and 0.061-unit difference, respectively, in natural-log–transformed D-dimer and together accounted for 1.8% of the total variance. When adjusted for nonsynonymous substitutions in F5 and FGA loci known to be associated with D-dimer levels, there was no evidence of an additional association at either locus. CONCLUSIONS: Three genes were associated with fibrin D-dimer levels. Of these 3, the F3 association was the strongest, and has not been previously reported.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

14.429

4.176