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Regenerative medicine and the hope for a cure.

Clin. Chest Med. 42, 365-373 (2021)
Postprint DOI PMC
Current therapeutic strategies have succeeded in slowing down the progression of idiopathic pulmonary fibrosis (IPF). Emerging evidence highlights IPF as a disease of aging and impaired regeneration. Novel antiaging and regenerative medicine approaches hold promise to be able to reverse disease and might present hope for a cure. Research focusing on a deeper understanding of lung stem cell populations and how these are regulated and altered in fibrotic disease continues to drive the field, and accompanied by earlier diagnosis, the adaptation of clinically relevant models and readouts for regeneration of diseased lung, ultimately paves the way for translation into clinics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Aging ; Cellular Senescence ; Developmental Pathways ; Ild ; Ipf ; Regeneration ; Translation; Idiopathic Pulmonary-fibrosis; Cellular Senescence; Lung Development; Stem-cells; Alveolar Progenitor; Aging Lung; Wnt; Mechanisms; Repair; Tgf
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 0272-5231
e-ISSN 1557-8216
Quellenangaben Band: 42, Heft: 2, Seiten: 365-373 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, Pa 19103-2899 Usa
Begutachtungsstatus Peer reviewed
POF Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Forschungsfeld(er) Lung Research
PSP-Element(e) G-503100-001
G-501800-311
PubMed ID 34024411
Erfassungsdatum 2021-06-28