PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Lassi, M. ; Tomar, A. ; Comas-Armangue, G. ; Vogtmann, R.* ; Dijkstra, D.J.* ; Corujo, D.* ; Gerlini, R. ; Darr, J. ; Scheid, F. ; Rozman, J. ; Aguilar-Pimentel, J.A. ; Koren, O.* ; Buschbeck, M.* ; Fuchs, H. ; Marschall, S. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Plösch, T.* ; Gellhaus, A.* ; Teperino, R.

Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors.

Sci. Adv. 7:eabg6424 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. Less is known about the role of paternal circadian rhythm for offspring health. Here, we disrupted circadian rhythm in male mice by night-restricted feeding and showed that paternal circadian disruption at conception is important for offspring feeding behavior, metabolic health, and oscillatory transcription. Mechanistically, our data suggest that the effect of paternal circadian disruption is not transferred to the offspring via the germ cells but initiated by corticosterone-based parental communication at conception and programmed during in utero development through a state of fetal growth restriction. These findings indicate paternal circadian health at conception as a newly identified determinant of offspring phenotypes.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
14.136
3.445
4
8
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Fetal-growth; Sex-differences; Glucocorticoids; Clocks; Mouse; Restriction; Obesity; Responses; Hormones; Stress
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 7, Heft: 22, Seiten: , Artikelnummer: eabg6424 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
POF Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-501900-069
G-500692-001
G-500600-001
G-501900-063
Förderungen German Center for Diabetes Research (DZD)
Fritz Thyssen Stiftung
Helmholtz Research Center Munich
Helmholtz Association
German Diabetes Research Center
FEDER/Ministerio de Ciencia e Innovacion-Agencia Estatal de Investigacion
Mercator Research Center Ruhr (MERCUR)
German Research Foundation (DFG)
Programm zur internen Forschungsforderung Essen (IFORES)
German Federal Ministry of Education and Research
German Diabetes Research Center (DZD NEXT grant)
DOI 10.1126/sciadv.abg6424
WOS ID WOS:000655906900033
Scopus ID 85106552218
PubMed ID 34039610
Erfassungsdatum 2021-06-07
[➜Korrektur melden]