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Mühlbacher, T. ; Amann, K.* ; Mahling, M. ; Nadalin, S.* ; Heyne, N. ; Guthoff, M.

Successful long-term management of recurrent focalsegmental glomerulosclerosis after kidneytransplantation with costimulation blockade.

Clin. Kidney J. 14, 1691-1693 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Recurrence of primary focal segmental glomerulosclerosis (FSGS) occurs in up to 50% of patients after kidney transplantation and is associated with poor allograft outcome. Novel therapeutic concepts directly target podocyte function via B7-1 with inconsistent response. We present the case of a 19-year-old patient with recurrent primary FSGS early after living donor kidney transplantation. Plasmapheresis and rituximab did not induce remission. Repetitive abatacept administration was able to achieve partial remission. Maintenance immunosuppression was subsequently switched to a belatacept-based calcineurin inhibitor-free immunosuppression, resulting in sustained complete remission with excellent allograft function throughout a follow-up of >56 months.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter B7-1 ; Belatacept ; Focal Segmental Glomerulosclerosis ; Kidney Transplantation ; Nephrotic Syndrome ; Recurrence; B7-1
ISSN (print) / ISBN 2048-8505
e-ISSN 2048-8513
Zeitschrift Clinical Kidney Journal
Quellenangaben Band: 14, Heft: 6, Seiten: 1691-1693 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Great Clarendon St, Oxford Ox2 6dp, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Open Access Publishing Fund of University of Tubingen
Deutsche Forschungsgemeinschaft