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Müller, B.W.* ; Hinney, A.* ; Scherbaum, N.* ; Weimar, C.* ; Kleinschnitz, C.* ; Peters, T.* ; Hochfeld, L.* ; Pechlivanis, S. ; Stang, A.* ; Jokisch, M.* ; Kowall, B.*

Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55-87 years.

Sci. Rep. 11, 13852:13852 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition tests (immediate and delayed word list, Trail-Making Test [TMT] part A and B, Maze test, interference condition of the Stroop color-word test, verbal fluency) and their associations with Klotho KL-VS haplotype. The Klotho KL-VS haplotype is classified by the V-allele at SNP rs9536314 (F352V) and the S-allele at SNP rs9527025 (C370S). Heterozygotes for the KL-VS haplotype were compared with non-carriers. Analyses were performed in 1812 subjects (55-87 years). We found consistent but only slightly lower performance in heterozygous carriers of the KL-VS haplotype in all tasks with Z-scores ranging between Z = - 0.042 (verbal fluency) and - 0.17 (TMT part A). Differences between carriers and non-carriers were similar for men and women for all tests but TMT part B (interaction contrast = 8.4 s (95% CI - 2.3; 19.1)). While cognition declined with age, we found an effect modification by age (55-65 years, 66-75 years, > 75 years). In the 66-75 years KL-VS heterozygous age group, lower performance was seen in memory, visual attention and motor speed. Contrary to our hypothesis, heterozygous carriers of the KL-VS haplotype did not show enhanced performance in cognitive tests in our study.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Functional Variant; Plasma Klotho; Gene; Association; Mortality; Risk
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 11, Heft: 1, Seiten: 13852 Artikelnummer: 13852 Supplement: ,
Verlag Springer
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Asthma and Allergy Prevention (IAP)
Förderungen Heinz Nixdorf Foundation
German Research Council (DFG)
German Ministry of Education and Science [BMBF]
Ministry of Innovation, Science, Research and Technology, North Rhine-Westphalia (MIWFT-NRW)
Janssen
Merck KG
Philips
ResMed Foundation
Roche Diagnostics
Sarstedt AGCo
Siemens HealthCare Diagnostics
Volkswagen Foundation
Imatron/GE-Imatron
Celgene GmbH Munchen
Dr. Werner-Jackstadt Stiftung
Else Kroner-Fresenius-Stiftung
German Social Accident Insurance [DGUV]
Competence Network for HIV/AIDS
IFORES of the University Duisburg-Essen
European Union
German Competence Network Heart Failure
Kulturstiftung Essen
Protein Research Unit within Europe (PURE)
Projekt DEAL