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Müller, B.W.* ; Hinney, A.* ; Scherbaum, N.* ; Weimar, C.* ; Kleinschnitz, C.* ; Peters, T.* ; Hochfeld, L.* ; Pechlivanis, S. ; Stang, A.* ; Jokisch, M.* ; Kowall, B.*

Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55-87 years.

Sci. Rep. 11, 13852:13852 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition tests (immediate and delayed word list, Trail-Making Test [TMT] part A and B, Maze test, interference condition of the Stroop color-word test, verbal fluency) and their associations with Klotho KL-VS haplotype. The Klotho KL-VS haplotype is classified by the V-allele at SNP rs9536314 (F352V) and the S-allele at SNP rs9527025 (C370S). Heterozygotes for the KL-VS haplotype were compared with non-carriers. Analyses were performed in 1812 subjects (55-87 years). We found consistent but only slightly lower performance in heterozygous carriers of the KL-VS haplotype in all tasks with Z-scores ranging between Z = - 0.042 (verbal fluency) and - 0.17 (TMT part A). Differences between carriers and non-carriers were similar for men and women for all tests but TMT part B (interaction contrast = 8.4 s (95% CI - 2.3; 19.1)). While cognition declined with age, we found an effect modification by age (55-65 years, 66-75 years, > 75 years). In the 66-75 years KL-VS heterozygous age group, lower performance was seen in memory, visual attention and motor speed. Contrary to our hypothesis, heterozygous carriers of the KL-VS haplotype did not show enhanced performance in cognitive tests in our study.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Functional Variant; Plasma Klotho; Gene; Association; Mortality; Risk
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 11, Heft: 1, Seiten: 13852 Artikelnummer: 13852 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Asthma and Allergy Prevention (IAP)
Förderungen Heinz Nixdorf Foundation
German Research Council (DFG)
German Ministry of Education and Science [BMBF]
Ministry of Innovation, Science, Research and Technology, North Rhine-Westphalia (MIWFT-NRW)
Janssen
Merck KG
Philips
ResMed Foundation
Roche Diagnostics
Sarstedt AGCo
Siemens HealthCare Diagnostics
Volkswagen Foundation
Imatron/GE-Imatron
Celgene GmbH Munchen
Dr. Werner-Jackstadt Stiftung
Else Kroner-Fresenius-Stiftung
German Social Accident Insurance [DGUV]
Competence Network for HIV/AIDS
IFORES of the University Duisburg-Essen
European Union
German Competence Network Heart Failure
Kulturstiftung Essen
Protein Research Unit within Europe (PURE)
Projekt DEAL