PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
McCartney, D.L.* ; Min, J.L.* ; Richmond, R.C.* ; Lu, A.T.* ; Sobczyk, M.K.* ; Davies, G.* ; Broer, L.* ; Guo, X.* ; Jeong, A.* ; Jung, J.* ; Kasela, S.* ; Katrinli, S.* ; Kuo, P.L.* ; Matias-Garcia, P.R. ; Mishra, P.P.* ; Nygaard, M.* ; Palviainen, T.* ; Patki, A.* ; Raffield, L.M.* ; Ratliff, S.M.* ; Richardson, T.G.* ; Robinson, O.* ; Soerensen, M.* ; Sun, D.* ; Tsai, P.C.* ; van der Zee, M.D.* ; Walker, R.M.* ; Wang, X.* ; Wang, Y.* ; Xia, R.* ; Xu, Z.* ; Yao, J.* ; Zhao, W.* ; Correa, A.* ; Boerwinkle, E.* ; Dugué, P.A.* ; Durda, P.* ; Elliott, H.R.* ; Gieger, C. ; de Geus, E.J.C.* ; Harris, S.E.* ; Hemani, G.* ; Imboden, M.* ; Kähönen, M.* ; Kardia, S.L.R.* ; Kresovich, J.K.* ; Li, S.* ; Lunetta, K.L.* ; Mangino, M.* ; Mason, D.* ; McIntosh, A.M.* ; Mengel-From, J.* ; Moore, A.Z.* ; Murabito, J.M.* ; Ollikainen, M.* ; Pankow, J.S.* ; Pedersen, N.L.* ; Peters, A. ; Polidoro, S.* ; Porteous, D.J.* ; Raitakari, O.* ; Rich, S.S.* ; Sandler, D.P.* ; Sillanpää, E.* ; Smith, A.K.* ; Southey, M.C.* ; Strauch, K. ; Tiwari, H.* ; Tanaka, T.* ; Tillin, T.* ; Uitterlinden, A.G.* ; Van Den Berg, D.J.* ; van Dongen, J.* ; Wilson, J.G.* ; Wright, J.* ; Yet, I.* ; Arnett, D.* ; Bandinelli, S.* ; Bell, J.T.* ; Binder, A.M.* ; Boomsma, D.I.* ; Chen, W.* ; Christensen, K.* ; Conneely, K.N.* ; Elliott, P.* ; Ferrucci, L.* ; Fornage, M.* ; Hägg, S.* ; Hayward, C.* ; Irvin, M.R.* ; Kaprio, J.* ; Lawlor, D.A.* ; Lehtimäki, T.* ; Lohoff, F.W.* ; Milani, L.* ; Milne, R.L.* ; Probst-Hensch, N.* ; Reiner, A.P.* ; Ritz, B.* ; Rotter, J.I.* ; Smith, J.A.* ; Taylor, J.A.* ; van Meurs, J.B.J.* ; Vineis, P.* ; Waldenberger, M. ; Deary, I.J.* ; Relton, C.L.* ; Horvath, S.* ; Marioni, R.E.*

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.

Genome Biol. 22:194 (2021)
Postprint Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. RESULTS: Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci associated with the Horvath clock and expression of transcripts encoding genes linked to lipid metabolism and immune function. Notably, these loci are independent of those reported to regulate DNA methylation levels at constituent clock CpGs. A polygenic score for GrimAge acceleration showed strong associations with adiposity-related traits, educational attainment, parental longevity, and C-reactive protein levels. CONCLUSION: This study illuminates the genetic architecture underlying epigenetic aging and its shared genetic contributions with lifestyle factors and longevity.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
13.583
0.000
2
11
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dna Methylation ; Epigenetic Clock ; Gwas; Mendelian Randomization; Susceptibility Loci; Age; Metaanalysis; Gwas; Enrichment; Regression; Insights; Provides; Blood
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 1474-760X
e-ISSN 1465-6906
Zeitschrift Genome Biology
Quellenangaben Band: 22, Heft: 1, Seiten: , Artikelnummer: 194 Supplement: ,
Verlag BioMed Central
Verlagsort Campus, 4 Crinan St, London N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-001
G-504091-004
G-504000-010
G-504100-001
Förderungen Medical Research Council
Cancer Research UK
Alzheimer's Research UK
NIH HHS
DOI 10.1186/s13059-021-02398-9
WOS ID WOS:000671146200002
Scopus ID 85109008239
PubMed ID 34187551
Erfassungsdatum 2021-07-30
[➜Korrektur melden]