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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Diversity of T helper and regulatory T cells and their contribution to the pathogenesis of allergic diseases.
In:. Berlin ; Heidelberg: Springer, 2021. 265-296 (Handb. Exp. Pharmacol. ; 268)
T helper (Th) and regulatory T (Treg) cells represent important effectors of adaptive immunity. They mediate communication between the immune system and tissue sites and thereby coordinate effective defense against environmental threats or maintain tolerance, respectively. Since the discovery of two prototypic T helper cells, Th1 and Th2, additional phenotypic and functional distinct subsets have been described ranging from Th17, Th22, Th9, and T follicular helper cells. The same holds true for regulatory T cells that represent a family with functionally distinct subsets characterized by co-expression of the transcription factors T-bet, Gata3, or RORγt. Here, we summarize the current knowledge on differentiation and function of T helper and regulatory T cell subsets and discuss their lineage stability versus plasticity towards other subsets. In addition, we highlight the direct and indirect contribution of each subset to the pathology of allergies and indicate novel therapies for specific targeting the effector functions of T helper and regulatory T cells.
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Publikationstyp
Artikel: Sammelbandbeitrag/Buchkapitel
Schlagwörter
Allergy ; Plasticity ; Regulatory T Cells (treg) ; T Helper Cells (th Cells)
ISSN (print) / ISBN
0171-2004
Zeitschrift
Handbook of Experimental Pharmacology
Quellenangaben
Band: 268,
Seiten: 265-296
Verlag
Springer
Verlagsort
Berlin ; Heidelberg
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Allergy Research (IAF)