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Fuse your mitochondria, lose appetite: An anorexic, anti-obesity sphingolipid.
EMBO Mol. Med.:e14618 (2021)
Aberrant production of ceramides, the precursors of complex sphingolipids, is a hallmark of obesity and strongly linked to metabolic dysfunction (Meikle and Summers 2017). Ceramides are formed by recycling or de novo synthesis from sphingosine and a fatty acid side chain moiety. The side chain length determines lipotoxicity of ceramides, as those composed of C16:0 or C18:0 side chains are toxic whereas those with C24:0 or C24:1 are not (Meikle and Summers 2017). Counteracting the deleterious effects of high-fat diets (HFDs) rich in saturated fat either by inhibiting synthesis or by promoting degradation of ceramides mitigates insulin resistance and ectopic lipid accumulation (Meikle and Summers 2017). However, drugs that safely and selectively target ceramide metabolism have failed to translate into metabolic benefit in human trials so far.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Editorial
Schlagwörter
Er Stress; Mff
ISSN (print) / ISBN
1757-4676
e-ISSN
1757-4684
Zeitschrift
EMBO Molecular Medicine
Quellenangaben
Artikelnummer: e14618
Verlag
Wiley
Verlagsort
Chichester
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Cancer (IDC)
Förderungen
DFG