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Kifer, D.* ; Louca, P.* ; Cvetko, A.* ; Deriš, H.* ; Cindrić, A.* ; Grallert, H. ; Peters, A. ; Polasek, O.* ; Gornik, O.* ; Mangino, M.* ; Spector, T.D.* ; Valdes, A.M.* ; Padmanabhan, S.* ; Gieger, C. ; Lauc, G.* ; Menni, C.*

N-glycosylation of immunoglobulin G predicts incident hypertension.

J. Hypertens. 39, 2527-2533 (2021)
Postprint DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
OBJECTIVES: Glycosylation of immunoglobulin G (IgG) is an important regulator of the immune system and has been implicated in prevalent hypertension.The aim of this study is to investigate whether the IgG glycome begins to change prior to hypertension diagnosis by analysing the IgG glycome composition in a large population-based female cohort with two independent replication samples. METHODS: We included 989 unrelated cases with incident hypertension and 1628 controls from the TwinsUK cohort (mean follow-up time of 6.3 years) with IgG measured at baseline by ultra-performance liquid chromatography and longitudinal BP measurement available. We replicated our findings in 106 individuals from the 10 001 Dalmatians and 729 from KORA S4. Cox regression mixed models were applied to identify changes in glycan traits preincident hypertension, after adjusting for age, mean arterial pressure, BMI, family relatedness and multiple testing (FDR < 0.1). Significant IgG-incident hypertension associations were replicated in the two independent cohorts by leveraging Cox regression mixed models in the 10 001 Dalmatians and logistic regression models in the KORA cohort. RESULTS: We identified and replicated four glycan traits, incidence of bisecting GlcNAc, GP4, GP9 and GP21, that are predictive of incident hypertension after adjusting for confoundes and multiple testing [hazard ratio (95% CI) ranging from 0.45 (0.24-0.84) for GP21 to 2.9 (1.5-5.68) for GP4]. We then linearly combined the four replicated glycans and found that the glycan score correlated with incident hypertension, SBP and DBP. CONCLUSION: Our results suggest that the IgG glycome changes prior to the development of hypertension.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Basic Science Research ; Biomarkers ; Glycomics ; Incident Hypertension ; Risk Factors; Glycans; Risk; Biomarkers
ISSN (print) / ISBN 0263-6352
e-ISSN 1473-5598
Zeitschrift Journal of Hypertension
Quellenangaben Band: 39, Heft: 12, Seiten: 2527-2533 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Verlagsort Two Commerce Sq, 2001 Market St, Philadelphia, Pa 19103 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen European Structural and Investment Funds grant 'Croatian National Centre of Research Excellence in Personalized Healthcare'
Helmholtz Zentrum Munchen -German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
European Regional Development Fund grant 'CardioMetabolic'
European Structural and Investment Funds grant 'Centre of Competence in Molecular Diagnostics grant'
European Commission H2020 grant BackUP
King's College London
Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
National Institute for Health Research (NIHR) Clinical Research Facility
European Commission H2020 grants SYSCID
Wellcome Trust
Chronic Disease Research Foundation
State of Bavaria
Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
Bavarian State Ministry of Health and Care through the research project DigiMed Bayern
European Commission H2020 grant IMforFuture
Nottingham NIHR Biomedical Research Centre
MRC Covid-Rapid Response grant
UKRI
National Institute for Health Research (NIHR)
BHF Centre of Excellence
British Heart Foundation (BHF)
Medical Research Council (MRC)
Medical Research Council
Medical Research Council AimHy project grant