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Walz, S.* ; Wang, Q.* ; Zhao, X.* ; Hoene, M.* ; Häring, H.U.* ; Hennenlotter, J.* ; Maas, M.* ; Peter, A. ; Todenhöfer, T.* ; Stenzl, A.* ; Liu, X.* ; Lehmann, R. ; Xu, G.*

Comparison of the metabolome in urine prior and eight weeks after radical prostatectomy uncovers pathologic and molecular features of prostate cancer.

J. Pharm. Biomed. Anal. 205:114288 (2021)
Postprint DOI PMC
Open Access Green
Prostate cancer (PCa) is associated with cellular metabolism alterations leading to changes of the metabolome. So far, studies investigating these alterations mainly focused on comparisons of metabolite profiles of PCa patients and healthy controls. In the present study we compared for the first time metabolite profiles in a significant number of paired urine samples collected before and eight weeks after radical prostatectomy (rPX) in 34 patients with PCa. Our comprehensive non-targeted liquid chromatographic-mass spectrometric metabolomics approach covered > 3000 metabolite ion masses. We annotated 23 metabolites showing significant changes eight weeks after rPX. While the levels of uridine and six acylcarnitines in urine were increased before surgery, lower levels were detected for 16 metabolites, like e.g. citrate, phenyl-lactic acid, choline, myo-inositol, emphasizing a relevant pathophysiological role of these biomarkers and the associated metabolic pathways. These results have important implications for potential use of metabolome analyses for detection of prostate cancer and related pathologic and molecular features.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Metabolomics ; Prostate Cancer ; Radical Prostatectomy ; Urine; Citrate; Phenylacetate; Derivatives; Diagnosis; Markers; Cycle; Acid
ISSN (print) / ISBN 0731-7085
e-ISSN 0731-7085
Zeitschrift Journal of Pharmaceutical and Biomedical Analysis : JPBA
Quellenangaben Band: 205, Heft: , Seiten: , Artikelnummer: 114288 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen National Natural Science Foundation of China
National Key Research and Development Program of China
Medical Faculty of the Eberhard Karls University Tuebingen
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