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Huang, S. ; Blutke, A. ; Feuchtinger, A. ; Klemm, U.* ; Zachariah Tom, R. ; Hofmann, S.M. ; Stiel, A.C.* ; Ntziachristos, V.

Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice.

EMBO Mol. Med. 13:e13490 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The increasing worldwide prevalence of obesity, fatty liver diseases and the emerging understanding of the important roles lipids play in various other diseases is generating significant interest in lipid research. Lipid visualization in particular can play a critical role in understanding functional relations in lipid metabolism. We investigated the potential of multispectral optoacoustic tomography (MSOT) as a novel modality to non-invasively visualize lipids in laboratory mice around the 930nm spectral range. Using an obesity-induced non-alcoholic fatty liver disease (NAFLD) mouse model, we examined whether MSOT could detect and differentiate different grades of hepatic steatosis and monitor the accumulation of lipids in the liver quantitatively over time, without the use of contrast agents, i.e. in label-free mode. Moreover, we demonstrate the efficacy of using the real-time clearance kinetics of indocyanine green (ICG) in the liver, monitored by MSOT, as a biomarker to evaluate the organ’s function and assess the severity of NAFLD. This study establishes MSOT as an efficient imaging tool for lipid visualization in preclinical studies, particularly for the assessment of NAFLD.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Biomarker ; Icg ; Lipid Metabolism ; Nafld ; Optoacoustic Imaging; Indocyanine Green Clearance; Liver Fat; In-vivo; Nafld
ISSN (print) / ISBN 1757-4676
e-ISSN 1757-4684
Zeitschrift EMBO Molecular Medicine
Quellenangaben Band: 13, Heft: 9, Seiten: , Artikelnummer: e13490 Supplement: ,
Verlag Wiley
Verlagsort Chichester
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Institute of Experimental Genetics (IEG)
Research Unit Analytical Pathology (AAP)
Institute of Diabetes and Regeneration Research (IDR)
Förderungen Projekt DEAL
Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF)/ExNet project "Innovative Intelligent Imaging" (i3-Helmholtz)
European Research Council (ERC) under the European Union
Deutsche Forschungsgemeinschaft (DFG), Germany