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Bergen, V. ; Soldatov, R.A.* ; Kharchenko, P.V.* ; Theis, F.J.

RNA velocity-current challenges and future perspectives.

Mol. Syst. Biol. 17:e10282 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
RNA velocity has enabled the recovery of directed dynamic information from single-cell transcriptomics by connecting measurements to the underlying kinetics of gene expression. This approach has opened up new ways of studying cellular dynamics. Here, we review the current state of RNA velocity modeling approaches, discuss various examples illustrating limitations and potential pitfalls, and provide guidance on how the ensuing challenges may be addressed. We then outline future directions on how to generalize the concept of RNA velocity to a wider variety of biological systems and modalities.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Rna Velocity ; Challenges ; Dynamics ; Limitations ; Perspectives; Single-cell; Gene-expression
ISSN (print) / ISBN 1744-4292
e-ISSN 1744-4292
Zeitschrift Molecular Systems Biology
Quellenangaben Band: 17, Heft: 8, Seiten: , Artikelnummer: e10282 Supplement: ,
Verlag EMBO Press
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Förderungen EC | H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC)
National Science Foundation (NSF)
Helmholtz Association ()
Deutsche Forschungsgemeinschaft (DFG)