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Feindor, M.* ; Heath, M.D.* ; Hewings, S.J.* ; Carreno Velazquez, T.L.* ; Blank, S. ; Grosch, J. ; Jakob, T.* ; Schmid-Grendelmeier, P.* ; Klimek, L.* ; Golden, D.B.K.* ; Skinner, M.A.* ; Kramer, M.F.*

Venom immunotherapy: From proteins to product to patient protection.

Toxins 13:616 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In this review, we outline and reflect on the important differences between allergen-specific immunotherapy for inhalant allergies (i.e., aeroallergens) and venom-specific immunotherapy (VIT), with a special focus on Venomil® Bee and Wasp. Venomil® is provided as a freeze-dried extract and a diluent to prepare a solution for injection for the treatment of patients with IgE-mediated allergies to bee and/or wasp venom and for evaluating the degree of sensitivity in a skin test. While the materials that make up the product have not changed, the suppliers of raw materials have changed over the years. Here, we consolidate relevant historical safety and efficacy studies that used products from shared manufacture supply profiles, i.e., products from Bayer or Hollister–Stier. We also consider the characterization and standardization of venom marker allergens, providing insights into manufacturing controls that have produced stable and consistent quality profiles over many years. Quality differences between products and their impacts on treatment outcomes have been a current topic of discussion and further research. Finally, we review the considerations surrounding the choice of depot adjuvant most suitable to augmenting VIT.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Adjuvant ; Allergy ; Honeybee Venom ; Hymenoptera ; Sensitization ; Venom ; Vit ; Wasp Venom; Api M 10; Hymenoptera Venom; Honeybee Venom; Allergen Immunotherapy; Molecular-cloning; Major Allergens; Aluminum; Bee; Recognition; Expression
e-ISSN 2072-6651
Zeitschrift Toxins
Quellenangaben Band: 13, Heft: 9, Seiten: , Artikelnummer: 616 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)