Gjermeni, E.* ; Kirstein, A.S.* ; Kolbig, F.* ; Kirchhof, M.* ; Bundalian, L.* ; Katzmann, J.L.* ; Laufs, U.* ; Blüher, M. ; Garten, A.* ; Le Duc, D.
Obesity–an update on the basic pathophysiology and review of recent therapeutic advances.
Biomolecules 11:1426 (2021)
Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hor-mones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat ab-sorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
Impact Factor
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Times Cited
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Anti-obesity Drugs ; Diabetes Mellitus ; Energy Balance ; Obesity ; Obesity Metabolism; Glucagon-like Peptide-1; Brown Adipose-tissue; Controlled-release Phentermine/topiramate; Gastric-inhibitory Polypeptide; Ghrelin Receptor Mutations; Type-2 Diabetes-mellitus; Diet-induced Obesity; Reduces Food-intake; Induced Weight-loss; Pancreatic-polypeptide
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2021
Prepublished im Jahr
HGF-Berichtsjahr
2021
ISSN (print) / ISBN
2218-273X
e-ISSN
2218-273X
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 11,
Heft: 10,
Seiten: ,
Artikelnummer: 1426
Supplement: ,
Reihe
Verlag
MDPI
Verlagsort
Basel
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
Institut(e)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s)
30201 - Metabolic Health
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-506501-001
Förderungen
Project DEAL
Clinician Scientist Programm, Medizinische Fakultaet der Universitaet Leipzig
German Research Foundation
Copyright
Erfassungsdatum
2021-10-08