Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
Verlagsversion
Forschungsdaten
DOI
PMC
 |
Open Access Gold |
|
möglich sobald bei der ZB eingereicht worden ist.
Mitochondrial impairment by MitobloCK-6 inhibits liver cancer cell proliferation.
Front. Cell Dev. Biol. 9:725474 (2021)
Verlagsversion
Forschungsdaten
DOI
PMC
Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS). Upregulation of ALR was observed in multiple forms of cancer, among them hepatocellular carcinoma (HCC). To shed light into ALR function in HCC, we used MitoBloCK-6 to pharmacologically inhibit ALR, resulting in profound mitochondrial impairment and cancer cell proliferation deficits. These effects were mostly reversed by supplementation with bioavailable hemin b, linking ALR function to mitochondrial iron homeostasis. Since many tumor cells are known for their increased iron demand and since increased iron levels in cancer are associated with poor clinical outcome, these results help to further advance the intricate relation between iron and mitochondrial homeostasis in liver cancer.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Mitochondria ; Hcc ; Disulfide Relay System ; Iron ; Heme; Sulfhydryl Oxidase; Intermembrane Space; Protein; Expression; Iron; Regeneration; Metabolism; Maturation; Sorafenib; Induction
ISSN (print) / ISBN
2296-634X
e-ISSN
2296-634X
Zeitschrift
Frontiers in cell and developmental biology
Quellenangaben
Band: 9,
Artikelnummer: 725474
Verlag
Frontiers
Verlagsort
Lausanne
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Molecular Toxicology and Pharmacology (TOXI)
Institute of Health Economics and Health Care Management (IGM)
CF Metabolomics & Proteomics (CF-MPC)
Research Unit Analytical BioGeoChemistry (BGC)
Institute of Health Economics and Health Care Management (IGM)
CF Metabolomics & Proteomics (CF-MPC)
Research Unit Analytical BioGeoChemistry (BGC)
Förderungen
FEDER/COMPETE
Foundation for Science and Technology (FCT)
European Unions Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant
Foundation for Science and Technology (FCT)
European Unions Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant