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möglich sobald bei der ZB eingereicht worden ist.
100 Years of insulin: Lifesaver, immune target, and potential remedy for prevention.
Med. 2, 1120-1137 (2021)
In this review, we bring our personal experiences to showcase insulin from its breakthrough discovery as a life-saving drug 100 years ago to its uncovering as the autoantigen and potential cause of type 1 diabetes and eventually as an opportunity to prevent autoimmune diabetes. The work covers the birth of insulin to treat patients, which is now 100 years ago; the development of human insulin, insulin analogs, devices, and the way into automated insulin delivery; the realization that insulin is the primary autoimmune target of type 1 diabetes in children; novel approaches of immunotherapy using insulin for immune tolerance induction; the possible limitations of insulin immunotherapy; and an outlook on how modern vaccines could remove the need for another 100 years of insulin therapy.
Impact Factor
Scopus SNIP
Scopus
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0.000
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1
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Autoimmunity ; Automated Insulin Delivery ; Insulin ; Insulin Autoantibody ; Insulin Device ; Insulin Immunotherapy ; Insulin Pump ; Tolerance ; Treg ; Type 1 Diabetes
Sprache
englisch
Veröffentlichungsjahr
2021
HGF-Berichtsjahr
2021
ISSN (print) / ISBN
2666-6359
e-ISSN
2666-6340
Zeitschrift
Med (N Y)
Quellenangaben
Band: 2,
Heft: 10,
Seiten: 1120-1137
Verlag
Cell Press
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)
Institute of Diabetes Research (IDF)
Research Unit Type 1 Diabetes Immunology (TDI)
Institute of Diabetes Research (IDF)
Research Unit Type 1 Diabetes Immunology (TDI)
POF Topic(s)
90000 - German Center for Diabetes Research
30201 - Metabolic Health
30201 - Metabolic Health
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e)
G-502600-006
G-502100-001
G-502191-001
G-502100-001
G-502191-001
Förderungen
NIDDK NIH HHS
Scopus ID
85116486857
PubMed ID
34993499
Erfassungsdatum
2021-11-25