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van der Laan, C.M.* ; Morosoli-García, J.J.* ; van de Weijer, S.G.A.* ; Colodro-Conde, L.* ; Lupton, M.K.* ; Mitchell, B.L.* ; McAloney, K.* ; Parker, R.* ; Burns, J.M.* ; Hickie, I.B.* ; Pool, R.* ; Hottenga, J.J.* ; Martin, N.G.* ; Medland, S.E.* ; Nivard, M.G.* ; Boomsma, D.I.* ; ACTION Consortium (Thiering, E.) ; ACTION Consortium (Standl, M.) ; ACTION Consortium (Heinrich, J.)

Continuity of genetic risk for aggressive behavior across the life-course.

Behav. Genet. 51, 592-606 (2021)

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We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.

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