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Lange, M.* ; Angelidou, G.* ; Ni, Z.* ; Criscuolo, A.* ; Schiller, J.* ; Blüher, M. ; Fedorova, M.*

AdipoAtlas: A reference lipidome for human white adipose tissue.

Cell Rep. Med. 2:100407 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders. Remodeling of WAT lipidome in obesity and associated comorbidities can explain disease etiology and provide valuable diagnostic and prognostic markers. To support understanding of WAT lipidome remodeling at the molecular level, we provide in-depth lipidomics profiling of human subcutaneous and visceral WAT of lean and obese individuals. We generate a human WAT reference lipidome by performing tissue-tailored preanalytical and analytical workflows, which allow accurate identification and semi-absolute quantification of 1,636 and 737 lipid molecular species, respectively. Deep lipidomic profiling allows identification of main lipid (sub)classes undergoing depot-/phenotype-specific remodeling. Previously unanticipated diversity of WAT ceramides is now uncovered. AdipoAtlas reference lipidome serves as a data-rich resource for the development of WAT-specific high-throughput methods and as a scaffold for systems medicine data integration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Ceramides ; Human White Adipose Tissue ; Lc-ms/ms ; Lipid Identification ; Lipid Metabolism ; Lipidomics ; Obesity ; Plasmalogens ; Semi-absolute Lipid Quantification ; Sphingolipids ; Subcutaneous White Adipose Tissue ; Triacylglycerols ; Visceral White Adipose Tissue
ISSN (print) / ISBN 2666-3791
e-ISSN 2666-3791
Zeitschrift Cell Reports Medicine
Quellenangaben Band: 2, Heft: 10, Seiten: , Artikelnummer: 100407 Supplement: ,
Verlag Cell Press
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Förderungen Bundesministerium fur Bildung und Forschung (BMBF)
Bayer
AstraZeneca
Amgen
Boehringer Ingelheim