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Wagner, R. ; Eckstein, S.S. ; Yamazaki, H.* ; Gerst, F. ; Machann, J. ; Jaghutriz, B.A. ; Schürmann, A.* ; Solimena, M. ; Singer, S.R.* ; Königsrainer, A.* ; Birkenfeld, A.L. ; Häring, H.-U. ; Fritsche, A. ; Ullrich, S. ; Heni, M.

Metabolic implications of pancreatic fat accumulation.

Nat. Rev. Endocrinol. 18, 43–54 (2022)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received considerable attention, pancreatic fat has become an important area of research throughout the past 10 years. While a number of diagnostic approaches are available to quantify pancreatic fat, multi-echo Dixon MRI is currently the most developed method. Initial studies have shown associations between pancreatic fat and the metabolic syndrome, impaired glucose metabolism and type 2 diabetes mellitus. Pancreatic fat is linked to reduced insulin secretion, at least under specific circumstances such as prediabetes, low BMI and increased genetic risk of type 2 diabetes mellitus. This Review summarizes the possible causes and metabolic consequences of pancreatic fat accumulation. In addition, potential therapeutic approaches for addressing pancreatic fat accumulation are discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Beta-cell Function; Stimulated Insulin-secretion; Fetuin-a; Cystic-fibrosis; Adipose-tissue; Hyperechogenic Pancreas; Quantitative Assessment; Clinical-significance; Increased Lipolysis; Bariatric Surgery
Sprache englisch
Veröffentlichungsjahr 2022
Prepublished im Jahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Zeitschrift Nature Reviews - Endocrinology
Quellenangaben Band: 18, Heft: , Seiten: 43–54 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
G-502600-001
Förderungen JSPS KAKENHI
Federal Ministry of Education and Research (BMBF)
DOI 10.1038/s41574-021-00573-3
WOS ID WOS:000709265500001
Scopus ID 85117395885
PubMed ID 34671102
Erfassungsdatum 2021-10-27
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