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Einwich, A.* ; Seth, P.K.* ; Bartölke, R.* ; Bolte, P.* ; Feederle, R. ; Dedek, K.* ; Mouritsen, H.*

Localisation of cryptochrome 2 in the avian retina.

J. Comp. Physiol. A -Neuroethol. Sens. Neural Behav. Physiol., DOI: 10.1007/s00359-021-01506-1 (2021)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Cryptochromes are photolyase-related blue-light receptors acting as core components of the mammalian circadian clock in the cell nuclei. One or more members of the cryptochrome protein family are also assumed to play a role in avian magnetoreception, but the primary sensory molecule in the retina of migratory birds that mediates light-dependent magnetic compass orientation has still not been identified. The mRNA of cryptochrome 2 (Cry2) has been reported to be located in the cell nuclei of the retina, but Cry2 localisation has not yet been demonstrated at the protein level. Here, we provide evidence that Cry2 protein is located in the photoreceptor inner segments, the outer nuclear layer, the inner nuclear layer and the ganglion cell layer in the retina of night-migratory European robins, homing pigeons and domestic chickens. At the subcellular level, we find Cry2 both in the cytoplasm and the nucleus of cells residing in these layers. This broad nucleic expression rather points to a role for avian Cry2 in the circadian clock and is consistent with a function as a transcription factor, analogous to mammalian Cry2, and speaks against an involvement in magnetoreception.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Chicken ; Circadian Clock ; Erithacus Rubecula ; Magnetic Compass ; Migratory Orientation; Blue-light Photoreceptors; Long-distance Navigation; Circadian Clock; Molecular Analysis; Magnetic-field; Magnetoreception; Expression; Protein; Birds; Cry2
ISSN (print) / ISBN 0340-7594
e-ISSN 1432-1351
Zeitschrift Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Verlag Springer
Verlagsort Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CF Monoclonal Antibodies (CF-MAB)
Förderungen Air Force Office of Scientific Research (Air Force Materiel Command USAF award)
DARPA (QuBE)
ERC Synergy Grant
Deutsche Forschungsgemeinschaft
Niedersachsisches Ministerium fur Wissenschaft und Kultur
Lichtenberg Professorship from the Volkswagen Stiftung
Projekt DEAL