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Doersam, A.F.* ; Moser, J. ; Throm, J.* ; Weiss, M.* ; Zipfel, S.* ; Micali, N.* ; Preissl, H. ; Giel, K.E.*

Maternal eating disorder severity is associated with increased latency of foetal auditory event-related brain responses.

Eur. Eat. Disord. Rev., DOI: 10.1002/erv.2870 (2021)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Objective: Maternal eating disorders (EDs) are associated with adverse pregnancy and child outcomes. There is limited research investigating the influence of maternal EDs on foetal brain development. Method: Using foetal magnetoencephalography (fMEG), an auditory sequence was presented for 10 min to assess brain response latencies in foetuses of mothers with (n = 12) and without (n = 11) a history of anorexia nervosa (AN) in the third trimester of pregnancy. ED history and severity were assessed using the structured clinical expert interview eating disorder examination (EDE) and the self-report questionnaire EDE-Q. Results: Foetuses of mothers with AN showed delayed foetal brain responses to auditory stimulation compared to foetuses of control women. Self-reported ED symptom severity explained 34% of variance in foetal brain response latencies in the AN group. Conclusions: ED pathology was strongly associated with foetal brain response latencies in the third trimester with longer latencies in foetuses of women with a history of AN reporting more ED symptoms. Follow-up on the children is pivotal to investigate if fMEG outcomes are associated with later child development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Anorexia Nervosa ; Brain ; Development ; Eating Disorders ; Fmeg, Pregnancy ; Foetus
ISSN (print) / ISBN 1072-4133
e-ISSN 1099-0968
Zeitschrift European Eating Disorders Review
Verlag Wiley
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Stiftung Begabtenförderung Cusanuswerk
Medical Faculty Tuebingen