Li, W.B. ; Stangl, S.* ; Klapproth, A. ; Shevtsov, M.* ; Hernandez, A.* ; Kimm, M.A.* ; Schuemann, J.* ; Qiu, R.* ; Michalke, B. ; Bernal, M.A.* ; Li, J.* ; Hürkamp, K. ; Zhang, Y.* ; Multhoff, G.*
Application of high‐Z gold nanoparticles in targeted cancer radiotherapy—pharmacokinetic modeling, Monte Carlo simulation and radiobiological effect modeling.
Cancers 13:5370 (2021)
High‐Z gold nanoparticles (AuNPs) conjugated to a targeting antibody can help to improve tumor control in radiotherapy while simultaneously minimizing radiotoxicity to adjacent healthy tissue. This paper summarizes the main findings of a joint research program which applied AuNP‐conjugates in preclinical modeling of radiotherapy at the Klinikum rechts der Isar, Technical University of Munich and Helmholtz Zentrum München. A pharmacokinetic model of superparamagnetic iron oxide nanoparticles was developed in preparation for a model simulating.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Cancers ; Gold Nanoparticles ; X-rays ; Cmhsp70.1 ; Conjugation ; Targeted Radiotherapy ; Enhancement Effect ; Pharmacokinetic Model ; Monte Carlo Simulation ; Radiobiological Modeling; Computed-tomography Xfct; Dose Enhancement Therapy; Dna-damage; In-vitro; X-rays; Heat-shock-protein-70 Hsp70; Secondary Electrons; Contrast Agents; Ion Irradiation; Cellular Uptake
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2021
Prepublished im Jahr
HGF-Berichtsjahr
2021
ISSN (print) / ISBN
2072-6694
e-ISSN
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 13,
Heft: 21,
Seiten: ,
Artikelnummer: 5370
Supplement: ,
Reihe
Verlag
MDPI
Verlagsort
St Alban-anlage 66, Ch-4052 Basel, Switzerland
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30203 - Molecular Targets and Therapies
30202 - Environmental Health
Forschungsfeld(er)
Radiation Sciences
Environmental Sciences
PSP-Element(e)
G-501391-001
G-504800-002
Förderungen
TUM Graduate School Internationalization Grant
Technische Universitat Munchen (TUM) within the DFG funding
Ministry of Science and Higher Education of The Russian Federation
National Institutes of Health (NIH)/National Cancer Institute (NCI)
FAPESP foundation in Brazil
CNPq
DFG
Copyright
Erfassungsdatum
2021-12-15