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Li, W.B. ; Stangl, S.* ; Klapproth, A. ; Shevtsov, M.* ; Hernandez, A.* ; Kimm, M.A.* ; Schuemann, J.* ; Qiu, R.* ; Michalke, B. ; Bernal, M.A.* ; Li, J.* ; Hürkamp, K. ; Zhang, Y.* ; Multhoff, G.*

Application of high‐Z gold nanoparticles in targeted cancer radiotherapy—pharmacokinetic modeling, Monte Carlo simulation and radiobiological effect modeling.

Cancers 13:5370 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
High‐Z gold nanoparticles (AuNPs) conjugated to a targeting antibody can help to improve tumor control in radiotherapy while simultaneously minimizing radiotoxicity to adjacent healthy tissue. This paper summarizes the main findings of a joint research program which applied AuNP‐conjugates in preclinical modeling of radiotherapy at the Klinikum rechts der Isar, Technical University of Munich and Helmholtz Zentrum München. A pharmacokinetic model of superparamagnetic iron oxide nanoparticles was developed in preparation for a model simulating.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cancers ; Gold Nanoparticles ; X-rays ; Cmhsp70.1 ; Conjugation ; Targeted Radiotherapy ; Enhancement Effect ; Pharmacokinetic Model ; Monte Carlo Simulation ; Radiobiological Modeling; Computed-tomography Xfct; Dose Enhancement Therapy; Dna-damage; In-vitro; X-rays; Heat-shock-protein-70 Hsp70; Secondary Electrons; Contrast Agents; Ion Irradiation; Cellular Uptake
ISSN (print) / ISBN 2072-6694
Zeitschrift Cancers
Quellenangaben Band: 13, Heft: 21, Seiten: , Artikelnummer: 5370 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
Research Unit Analytical BioGeoChemistry (BGC)
Förderungen TUM Graduate School Internationalization Grant
Technische Universitat Munchen (TUM) within the DFG funding
Ministry of Science and Higher Education of The Russian Federation
National Institutes of Health (NIH)/National Cancer Institute (NCI)
FAPESP foundation in Brazil
CNPq
DFG