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Heilbronner, U.* ; Streit, F.* ; Vogl, T.* ; Senner, F.* ; Schaupp, S.K.* ; Reich-Erkelenz, D.* ; Papiol, S.* ; Oraki Kohshour, M.* ; Klöhn-Saghatolislam, F.* ; Kalman, J.L.* ; Heilbronner, M.* ; Gade, K.* ; Comes, A.L.* ; Budde, M.* ; Andlauer, T.F.M.* ; Anderson-Schmidt, H.* ; Adorjan, K.* ; Stürmer, T.* ; Loerbroks, A.* ; Amelang, M.* ; Poisel, E.* ; Foo, J.C.* ; Heilmann-Heimbach, S.* ; Forstner, A.J.* ; Degenhardt, F.* ; Zimmermann, J.* ; Wiltfang, J.* ; von Hagen, M.* ; Spitzer, C.* ; Schmauss, M.* ; Reininghaus, E.* ; Reimer, J.* ; Konrad, C.* ; Juckel, G.* ; Lang, F.U.* ; Jäger, M.* ; Figge, C.* ; Fallgatter, A.J.* ; Dietrich, D.E.* ; Dannlowski, U.* ; Baune, B.T.* ; Arolt, V.* ; Anghelescu, I.G.* ; Nöthen, M.M.* ; Witt, S.H.* ; Andreassen, O.A.* ; Chen, C.H.* ; Falkai, P.* ; Rietschel, M.* ; Schulze, T.G.* ; Schulte, E.C.

Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection.

BJPsych Open 7:e188 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus. Aims: We examined overlapping genetic underpinnings between major psychiatric disorders, personality traits and susceptibility to SARS-CoV-2 infection. Method: Linkage disequilibrium score regression was used to explore the genetic correlations of coronavirus disease 2019 (COVID-19) susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n = 1346) and the HeiDE (n = 3266) study), polygenic risk scores were used to analyse if a genetic association between, psychiatric disorders, personality traits and COVID-19 susceptibility exists in individual-level data. Results: We observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (P = 1.47 × 10-5; genetic correlation 0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies. Conclusions: We identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Covid-19 ; Extraversion ; Genetics ; Personality Traits ; Severe Mental Disorders; Extroversion; Disease
ISSN (print) / ISBN 2056-4724
e-ISSN 2056-4724
Zeitschrift BJPsych Open
Quellenangaben Band: 7, Heft: 6, Seiten: , Artikelnummer: e188 Supplement: ,
Verlag Cambridge Univ. Press
Verlagsort Edinburgh Bldg, Shaftesbury Rd, Cb2 8ru Cambridge, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
Helmholtz AI - FZJ (HAI - FZJ)
Förderungen NordForsk
ERA-NET NEURON grant 'SynSchiz-Linking synaptic dysfunction to disease mechanisms in schizophrenia-a multilevel investigation'
German Research Foundation (Deutsche Forschungsgemeinschaft; DFG)
DFG
Munich Clinician Scientist Program (MCSP)
German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under e:Med Program
German Federal Ministry of Education and Research (BMBF)
Dr. Lisa Oehler Foundation, Kassel (Germany)
Research Council of Norway
ERA-NET NEURON grant 'EMBED'