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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
From virus to inflammation: Mechanisms of RIG-I-induced IL-1β production.
Eur. J. Cell Biol. 91, 59-64 (2012)
Early detection of viruses by the innate immune system is critical for host defense. Antiviral immunity is initiated by germline encoded pattern recognition receptors (PRRs) that recognize viral pathogen-associated molecular patterns (PAMPs) such as nucleic acids. Intracellular PRRs then drive the production of interferons and cytokines to orchestrate immune responses. One key host factor that is critical for antiviral immunity and for systemic inflammatory reactions including fever is interleukin-1beta (IL-1β). Here we discuss current insights into the molecular mechanisms how the cytosolic RNA helicase RIG-I triggers NF-κB signaling and inflammasome activation specifically for RNA virus-induced IL-1β production.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
NOD like receptors; RIG-I-like helicases; CARD9; Inflammasome; NLRP3; IL-1β
ISSN (print) / ISBN
0171-9335
e-ISSN
1618-1298
Zeitschrift
European Journal of Cell Biology
Quellenangaben
Band: 91,
Heft: 1,
Seiten: 59-64
Verlag
Elsevier
Verlagsort
Jena, Germany
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed