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Ruland, J.

Return to homeostasis: Downregulation of NF-κB responses.

Nat. Immunol. 12, 709-714 (2011)
DOI PMC
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter t-cell-activation; alpha-mediated phosphorylation; negative feedback loop; editing enzyme a20; ikk-alpha; irak-m; deubiquitinating enzyme; gene-expression; innate immunity; signaling pathway
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Zeitschrift Nature Immunology
Quellenangaben Band: 12, Heft: 8, Seiten: 709-714 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY, USA
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOX)