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Lechner, A. ; Bohnacker, S. ; Esser-von Bieren, J.

Macrophage regulation & function in helminth infection.

Semin. Immunol. 53:101526 (2021)
Postprint DOI PMC
Open Access Green
Macrophages are innate immune cells with essential roles in host defense, inflammation, immune regulation and repair. During infection with multicellular helminth parasites, macrophages contribute to pathogen trapping and killing as well as to tissue repair and the resolution of type 2 inflammation. Macrophages produce a broad repertoire of effector molecules, including enzymes, cytokines, chemokines and growth factors that govern anti-helminth immunity and repair of parasite-induced tissue damage. Helminth infection and the associated type 2 immune response induces an alternatively activated macrophage (AAM) phenotype that – beyond driving host defense - prevents aberrant Th2 cell activation and type 2 immunopathology. The immune regulatory potential of macrophages is exploited by helminth parasites that induce the production of anti-inflammatory mediators such as interleukin 10 or prostaglandin E2 to evade host immunity. Here, we summarize current insights into the mechanisms of macrophage-mediated host defense and repair during helminth infection and highlight recent progress on the immune regulatory crosstalk between macrophages and helminth parasites. We also point out important remaining questions such as the translation of findings from murine models to human settings of helminth infection as well as long-term consequences of helminth-induced macrophage reprogramming for subsequent host immunity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Alternatively Activated Macrophages ; Helminth Infection ; Immune Regulation ; Immunometabolism ; Inflammation ; Tissue Repair ; Type 2 Immunity; Alternatively Activated Macrophages; Cysteine Protease Inhibitor; Acidic Mammalian Chitinase; Innate Immune Cells; Schistosoma-japonicum; Protective Immunity; Host Immunity; Brugia-malayi; Relm-alpha; B-cells
ISSN (print) / ISBN 1044-5323
e-ISSN 1044-5323
Zeitschrift Seminars in Immunology
Quellenangaben Band: 53, Heft: , Seiten: , Artikelnummer: 101526 Supplement: ,
Verlag Elsevier
Verlagsort 24-28 Oval Rd, London Nw1 7dx, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
Förderungen German Research Foundation (DFG)
Helmholtz Young Investigator grant by the Helmholtz Initiative and Networking fund