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Kammerl, I.E. ; Flexeder, C. ; Karrasch, S. ; Thorand, B. ; Heier, M. ; Peters, A. ; Schulz, H. ; Meiners, S.

Blood immunoproteasome activity is regulated by sex, age and in chronic inflammatory diseases: A first population-based study.

Cells 10:3336 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Dysfunction of the immunoproteasome has been implicated in cardiovascular and pulmonary diseases. Its potential as a biomarker for predicting disease stages, however, has not been investigated so far and population-based analyses on the impact of sex and age are missing. We here analyzed the activity of all six catalytic sites of the proteasome in isolated peripheral blood mononuclear cells obtained from 873 study participants of the KORA FF4 study using activity-based probes. The activity of the immuno-and standard proteasome correlated clearly with elevated leukocyte counts of study participants. Unexpectedly, we observed a strong sex dimorphism for proteasome activity with significantly lower immunoproteasome activity in women. In aging, almost all catalytic activities of the proteasome were activated in aged women while maintained upon aging in men. We also noted distinct sex-related activation patterns of standard and immunoproteasome active sites in chronic inflammatory diseases such as diabetes, cardiovascular diseases, asthma, or chronic obstructive pulmonary disease as determined by multiple linear regression modeling. Our data thus provides a conceptual framework for future analysis of immunoproteasome function as a bio-marker for chronic inflammatory disease development and progression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Age ; Asthma ; Cardiovascular Disease ; Chronic Obstructive Pulmonary Disease (copd) ; Diabetes ; Immunoproteasome ; Peripheral Blood Mononuclear Cells ; Population-based Study ; Sex; Ubiquitin-proteasome System; Reticulum Stress-response; Plasma Immunoproteasome; Oxidative Stress; Subunit Lmp2; Transcriptome; Degradation; Dysfunction; Inhibition; Expression
ISSN (print) / ISBN 2073-4409
e-ISSN 2073-4409
Zeitschrift Cells
Quellenangaben Band: 10, Heft: 12, Seiten: , Artikelnummer: 3336 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Institut(e) Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)
Förderungen Helmholtz Zentrum Munchen - German Research Center for Environmental Health