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Casuso, R.A.* ; Al Fazazi, S.* ; Plaza-Díaz, J.* ; Ruiz Ojeda, F.J. ; Rueda-Robles, A.* ; Aragón-Vela, J.* ; Huertas, J.R.*

Physiological doses of hydroxytyrosol modulate gene expression in skeletal muscle of exercised rats.

Life 11:1393 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
We tested whether physiological doses of hydroxytyrosol (HT) may alter the mRNA transcription of key metabolic genes in exercised skeletal muscle. Two groups of exercise-trained Wistar rats, HTlow and HTmid, were supplemented with 0.31 and 4.61 mg/kg/d of HT, respectively, for 10 weeks. Another two groups of rats were not supplemented with HT; one remained sedentary and the other one was exercised. After the experimental period, the soleus muscle was removed for qRT-PCR and western blot analysis. The consumption of 4.61 mg/kg/d of HT during exercise increased the mRNA expression of important metabolic proteins. Specifically, 4.61 mg/kg/d of HT may upregulate long-chain fatty acid oxidation, lactate, and glucose oxidation as well as mitochondrial Krebs cycle in trained skeletal muscle. However, a 4.61 mg/kg/d of HT may alter protein translation, as in spite of the increment showed by CD36 and GLUT4 at the mRNA level this was not translated to higher protein content.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Gene Expression ; Glycolysis ; Mitochondria ; Polyphenols; Virgin Olive Oil; Mitochondrial; Mct1; Antioxidant; Population; Increases; Reveals; Heart
ISSN (print) / ISBN 2075-1729
e-ISSN 2075-1729
Zeitschrift Life
Quellenangaben Band: 11, Heft: 12, Seiten: , Artikelnummer: 1393 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
Förderungen CTS-454
3650