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Filler, J. ; von Krüchten, R.* ; Wawro, N. ; Maier, L. ; Lorbeer, R.* ; Nattenmüller, J.* ; Thorand, B. ; Bamberg, F.* ; Peters, A. ; Schlett, C.L.* ; Linseisen, J. ; Rospleszcz, S.

Association of habitual dietary intake with liver iron—a population-based imaging study.

Nutrients 14:132 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Iron-related disorders of the liver can result in serious health conditions, such as liver cirrhosis. Evidence on the role of modifiable lifestyle factors like nutrition in liver iron storage is lacking. Thus, we aimed to assess the association of habitual diet with liver iron content (LIC). We investigated 303 participants from the population-based KORA-MRI study who underwent wholebody magnetic resonance imaging (MRI). Dietary habits were evaluated using repeated 24 h food lists and a food frequency questionnaire. Sex-stratified multiple linear regression models were applied to quantify the association between nutrition variables of interest and LIC, adjusting for liver fat content (LFC), energy intake, and age. Mean age of participants was 56.4 ± 9.0 years and 44.2% were female. Mean LIC was 1.23 ± 0.12 mg/g dry weight, with higher values in men than in women (1.26 ± 0.13 and 1.20 ± 0.10 mg/g, p < 0.001). Alcohol intake was positively associated with LIC (men: β = 1.94; women: β = 4.98, p-values <0.03). Significant negative associations with LIC were found for fiber (β = −5.61, p < 0.001) and potassium (β = −0.058, p = 0.034) for female participants only. Furthermore, LIC was highly correlated with liver fat content in both sexes. Our findings suggests that there are sex-specific associations of habitual dietary intake and LIC. Alcohol, fiber, and potassium may play a considerable role in liver iron metabolism.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Alcohol ; Diet ; Iron Metabolism ; Liver Iron ; Liver Iron Overload ; Mri ; Nutrition ; Population-based; Nutrition Examination Survey; Fatty Liver; Metabolic Syndrome; Alcohol-consumption; National-health; Vitamin-c; Absorption; Stores; Women; Disease
ISSN (print) / ISBN 2072-6643
e-ISSN 2072-6643
Zeitschrift Nutrients
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 132 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Independent Research Group Clinical Epidemiology (KEPI)
Förderungen Deutsche Forschungsgemeinschaft