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Rodriguez, R.* ; Schreiber, S.L.* ; Conrad, M.

Persister cancer cells: Iron addiction and vulnerability to ferroptosis.

Mol. Cell 82, 728-740 (2022)
Verlagsversion Postprint DOI PMC
Open Access Green
Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained occurrence of peroxidized phospholipids, which are subject to iron-mediated production of lethal oxygen radicals. This cell death modality has been detected across many organisms, including in mammals, where it can be used as a defense mechanism against pathogens or even harnessed by T cells to sensitize tumor cells toward effective killing. Conversely, ferroptosis is considered one of the main cell death mechanisms promoting degenerative diseases. Emerging evidence suggests that ferroptosis represents a vulnerability in certain cancers. Here, we critically review recent advances linking ferroptosis vulnerabilities of dedifferentiating and persister cancer cells to the dependency of these cells on iron, a potential Achilles heel for small-molecule intervention. We provide a perspective on the mechanisms reliant on iron that contribute to the persister cancer cell state and how this dependency may be exploited for therapeutic benefits.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Glutathione-peroxidase 4; Cystine/glutamate Antiporter; Promotes Ferroptosis; Lipid-peroxidation; Oxidative Stress; Stem-cells; Death; Inhibition; Mechanism; Complex
ISSN (print) / ISBN 1097-2765
e-ISSN 1097-4164
Zeitschrift Molecular Cell
Quellenangaben Band: 82, Heft: 4, Seiten: 728-740 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Metabolism and Cell Death (MCD)
Förderungen Else Kroner-Fresenius-Stiftung
Fondation Charles Defforey-Institut de France
Ligue contre le Cancer
Region Ile-de-France
National Cancer Institute's Cancer Target Discovery and Development (CTD2) Network
Deutsche Forschungsgemeinschaft (DFG)
German Federal Ministry of Education and Research (BMBF) VIP+ program NEURO-PROTEKT
Ministry of Science and Higher Education of The Russian Federation
ERC under the European Union's Horizon 2020 research and innovation program
European Research Council (ERC) under the European Union