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Garrett, L. ; da Silva Buttkus, P. ; Rathkolb, B. ; Gerlini, R. ; Becker, L. ; Sanz-Moreno, A. ; Seisenberger, C. ; Zimprich, A. ; Aguilar-Pimentel, J.A. ; Amarie, O.V. ; Cho, Y.-L. ; Kraiger, M. ; Spielmann, N. ; Calzada-Wack, J. ; Marschall, S. ; Busch, D.* ; Schmidt-Weber, C.B. ; Wolf, E.* ; Wurst, W. ; Fuchs, H. ; Gailus-Durner, V. ; Hölter, S.M. ; Hrabě de Angelis, M.

Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.

Dis. Model. Mech. 15:dmm049205 (2022)
Verlagsversion Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Understanding the shared genetic aetiology of psychiatric and medical comorbidity in neurodevelopmental disorders (NDDs) could improve patient diagnosis, stratification and treatment options. Rare TANC2 (Tetratricopeptide Repeat, Ankyrin Repeat and Coiled-Coil Containing 2) disrupting variants were disease-causing in NDD patients. This post-synaptic scaffold protein, essential for dendrite formation in synaptic plasticity, plays an unclarified but critical role in development. We here report a novel homozygous-viable Tanc2 disrupted function model where mutant mice were hyperactive and had impaired sensorimotor gating consistent with NDD patient psychiatric endophenotypes. Yet, a multi-systemic analysis revealed the pleiotropic effects of Tanc2 outside the brain such as growth failure and hepatocellular damage. This was associated with aberrant liver function including altered hepatocellular metabolism. Integrative analysis indicates that these disrupted Tanc2 systemic effects relate to interaction with Hippo developmental signalling pathway proteins and will increase the risk for comorbid somatic disease. This highlights how NDD gene pleiotropy can augment medical comorbidity susceptibility underscoring the benefit of holistic NDD patient diagnosis and treatment for which large-scale preclinical functional genomics can provide complementary pleiotropic gene function information.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Mouse Models ; Neurodevelopmental Disorder ; Somatic Comorbidity ; Tanc2
ISSN (print) / ISBN 1754-8403
e-ISSN 1754-8411
Zeitschrift Disease Models and Mechanisms
Quellenangaben Band: 15, Heft: 3, Seiten: , Artikelnummer: dmm049205 Supplement: ,
Verlag Company of Biologists
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
Institute for Allergy Research (IAF)
Förderungen Bundesministerium für Bildung und Forschung