PuSH - Publikationsserver des Helmholtz Zentrums München

Clayer, E. ; Frank, D.* ; Anderton, H.* ; Zhang, S.* ; Kueh, A.* ; Heim, V.* ; Nutt, S.L.* ; Chopin, M.* ; Bouillet, P.*

ZC3H12C expression in DCs is necessary to prevent lymphadenopathy of skin-draining lymph nodes.

Immunol. Cell Biol. 100, 160-173 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The role of RNA-binding proteins of the CCCH-containing family in regulating pro-inflammatory cytokine production and inflammation is increasingly recognized. We have identified ZC3H12C (Regnase-3) as a potential post-transcriptional regulator of Tumor necrosis factor expression and have investigated its role in vivo by generating Zc3h12c-deficient mice that express GFP instead of ZC3H12C. Zc3h12c-deficient mice develop hypertrophic lymph nodes. In the immune system, ZC3H12C expression is mostly restricted to the dendritic cell (DC) populations, and we show that DC-restricted ZC3H12C depletion is sufficient to cause lymphadenopathy. ZC3H12C can regulate Tnf mRNA stability via its RNAse activity in vitro, and we confirmed the role of Tnf in the development of lymphadenopathy. Finally, we found that loss of ZC3H12C did not impact the outcome of skin inflammation in the imiquimod-induced murine model of psoriasis, despite Zc3h12c being identified as a risk factor for psoriasis susceptibility in several GWAS studies. Our data suggest a role for ZC3H12C in DC-driven skin homeostasis.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Rna-binding Protein ; Regnase 3 ; Tumour Necrosis Factor ; Dendritic Cells ; Lymphadenopathy; Tumor-necrosis-factor; Au-rich Elements; Tnf-alpha; Mice; Promotes; Biosynthesis; Inflammation; Activation; Cytokines; Arthritis
ISSN (print) / ISBN 0818-9641
e-ISSN 1440-1711
Zeitschrift Immunology & cell biology
Quellenangaben Band: 100, Heft: 3, Seiten: 160-173 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
Förderungen Australian Government through the National Collaborative Research Infrastructure Strategy (NCRIS) program
Australian Phenomics Network (APN)
Arthritis Australia Zimmer fellowship
Australian NHMRC