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Rosberg, V.* ; Vishram-Nielsen, J.K.K.* ; Kristensen, A.M.D.* ; Pareek, M.* ; Sehested, T.S.G.* ; Nilsson, P.M.* ; Linneberg, A.* ; Palmieri, L.* ; Giampaoli, S.* ; Donfrancesco, C.* ; Kee, F.* ; Mancia, G.* ; Cesana, G.* ; Veronesi, G.* ; Grassi, G.* ; Kuulasmaa, K.* ; Salomaa, V.* ; Palosaari, T.* ; Sans, S.* ; Ferrieres, J.* ; Dallongeville, J.* ; Söderberg, S.* ; Moitry, M.* ; Drygas, W.* ; Tamosiunas, A.* ; Peters, A. ; Brenner, H.* ; Schöttker, B.* ; Grimsgaard, S.* ; Biering-Sørensen, T.* ; Olsen, M.H.*

Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project.

Prev. Med. Rep. 26:101700 (2022)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without established cardiovascular disease, and not on antihypertensive treatment. While BMI was reported in all, WHR and EFM were reported in ∼52,000 participants. Prognostic importance of anthropometric measurements and total-cholesterol was evaluated using adjusted Cox proportional-hazards regression, logistic regression, area under the receiver-operating-characteristic curve (AUCROC), and net reclassification improvement (NRI). The primary endpoint was MACE, a composite of stroke, myocardial infarction, or death from coronary heart disease. Age interacted significantly with anthropometric measures and total-cholesterol on MACE (P ≤ 0.003), and therefore age-stratified analyses (<50 versus ≥ 50 years) were performed. BMI, WHR, EFM, and total-cholesterol were independently associated with MACE (P ≤ 0.003) and resulted in significantly positive NRI when added to age, sex, smoking status, and systolic blood pressure. Only total-cholesterol increased discrimination ability (AUCROC difference; P < 0.001). In subjects < 50 years, the prediction model with total-cholesterol was superior to the model including BMI, but not superior to models containing WHR or EFM, while in those ≥ 50 years, the model with total-cholesterol was superior to all models containing anthropometric variables, whether assessed individually or combined. We found a potential role for replacing total-cholesterol with anthropometric measures for MACE-prediction among individuals < 50 years when laboratory measurements are unavailable, but not among those ≥ 50 years.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adipose Tissue ; Assessment, Risk ; Body Mass Index ; Cardiovascular Diseases ; Cholesterol ; Waist-hip Ratio
ISSN (print) / ISBN 2211-3355
e-ISSN 2211-3355
Zeitschrift Preventive medicine reports
Quellenangaben Band: 26, Heft: , Seiten: , Artikelnummer: 101700 Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen Medical Research Council
Seventh Framework Programme
Boehringer Ingelheim
Bayer
AstraZeneca
Swedish Heart and Lung Foundation
MORGAM Laboratories
ENGAGE
County council of V?stertbotten
CHANCES
AFFECT-EU
European Commission
Horizon 2020
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