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Jende, J.M.E.* ; Kender, Z.* ; Morgenstern, J.* ; Renn, P.* ; Mooshage, C.* ; Juerchott, A.* ; Kopf, S.* ; Nawroth, P.P. ; Bendszus, M.* ; Kurz, F.T.*

Fractional anisotropy and troponin T parallel structural nerve damage at the upper extremities in a group of patients with prediabetes and type 2 diabetes - a study using 3T magnetic resonance neurography.

Front. Neurosci. 15:741494 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BackgroundRecent studies have found that troponin T parallels the structural and functional decay of peripheral nerves at the level of the lower limbs in patients with type 2 diabetes (T2D). The aim of this study was to determine whether this finding can also be reproduced at the level of the upper limbs.MethodsTen patients with fasting glucose levels >100 mg/dl (five with prediabetes and five with T2D) underwent magnetic resonance neurography of the right upper arm comprising T2-weighted and diffusion weighted sequences. The fractional anisotropy (FA), an indicator for the structural integrity of peripheral nerves, was calculated in an automated approach for the median, ulnar, and radial nerve. All participants underwent additional clinical, serological, and electrophysiological assessments.ResultsHigh sensitivity Troponin T (hsTNT) and HbA1c were negatively correlated with the average FA of the median, ulnar and radial nerve (r = -0.84; p = 0.002 and r = -0.68; p = 0.032). Both FA and hsTNT further showed correlations with items of the Michigan Hand Outcome Questionnaire (r = -0.76; p = 0.010 and r = 0.87; p = 0.001, respectively). A negative correlation was found for hsTNT and HbA1c with the total Purdue Pegboard Test Score (r = -0.87; p = 0.001 and r = -0.68; p = 0.031).ConclusionThis study is the first to find that hsTNT and HbA1c are associated with functional and structural parameters of the nerves at the level of the upper limbs in patients with impaired glucose tolerance and T2D. Our results support the hypothesis that hyperglycemia-related microangiopathy, represented by elevated hsTNT levels, is a contributor to nerve damage in diabetic polyneuropathy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Diabetic Polyneuropathy ; Magnetic Resonance Neurography (mrn) ; Diffusion Tensor Imaging ; Microangiopathy ; High-sensitivity Troponin T; Peripheral Neuropathy; Fiber Loss; Painful; Prevalence; Risk
ISSN (print) / ISBN 1662-453X
Zeitschrift Frontiers in Neuroscience
Quellenangaben Band: 15, Heft: , Seiten: , Artikelnummer: 741494 Supplement: ,
Verlag Frontiers
Verlagsort Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Nichtpatentliteratur Publikationen
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen Heidelberg University Hospital
German Center of Diabetes Research (DZD)
German Research Council (DFG)
Deutsches Zentrum fur Diabetesforschung (DZD) e.V.
International Foundation for Research in Paraplegia
German Research Foundation
DFG
international Foundation for Research in paraplegia (IRP)
Novo Nordisk
Guerbet
Hoffmann-Klose foundation (Heidelberg University)
Stryker
Dietmar Hopp foundation
Siemens
European Union
Teva
Roche
Bayer
German Research Council