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β-glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping.
Immunol. Cell Biol. 100, 223-234 (2022)
Postprint
Forschungsdaten
DOI
PMC
Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensis (Nb) are mediated, at least in part, by IL-4-activated macrophages that bind and trap larvae in the lung. However, it is still not clear how host macrophages recognize the parasite. We utilized an in vitro co-culture system of bone marrow-derived macrophages and Nb infective larvae to screen for the possible ligand-receptor pair involved in macrophage attack of larvae. Competitive binding assays revealed an important role for β-glucan recognition in the process. We further identified a role for CD11b and the non-classical pattern recognition receptor ephrin-A2 (EphA2), but not the highly expressed β-glucan dectin-1 receptor, in this process of recognition. This work raises the possibility that parasitic nematodes synthesize β-glucans and identifies CD11b and Ephrin-A2 as important pattern recognition receptors involved in the host recognition of these evolutionary old pathogens. To our knowledge, this is the first time that EphA2 has been implicated in immune responses to a helminth.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Nippostrongylus Brasiliensis ; Macrophages ; Glucan ; Hookworms ; Recognition ; Trapping; Cells; Binding; Site; Glycoproteins; Infections; Protection; Dectin-1; Induce; Epha2
ISSN (print) / ISBN
0818-9641
e-ISSN
1440-1711
Zeitschrift
Immunology & cell biology
Quellenangaben
Band: 100,
Heft: 4,
Seiten: 223-234
Verlag
Springer
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Allergy Research (IAF)
Förderungen
National Institutes of Health
National Health and Medical Research Council (NHMRC) of Australia
EU Marie Curie Initial Training Network Grant: Infection BIOlogy training NETwork (INBIONET): Shaping the future of infectious diseases treatments
National Health and Medical Research Council (NHMRC) of Australia
EU Marie Curie Initial Training Network Grant: Infection BIOlogy training NETwork (INBIONET): Shaping the future of infectious diseases treatments