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Künzli, N.* ; Perez, L.* ; von Klot, S. ; Baldassarre, D.* ; Bauer, M.* ; Basagana, X.* ; Breton, C.* ; Dratva, J.* ; Elosua, R.* ; de Faire, U.* ; Fuks, K.* ; de Groot, E.* ; Marrugat, J.* ; Penell, J.* ; Seissler, J.* ; Peters, A. ; Hoffmann, B.*

Investigating air pollution and atherosclerosis in humans: Concepts and outlook.

Prog. Cardiovasc. Dis. 53, 334-343 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Although ambient particulate matter contributes to atherosclerosis in animal models, its role in atherogenesis in humans needs to be established. This article discusses concepts, study design, and choice of health outcomes to efficiently investigate the atherogenic role of ambient air pollution, with an emphasis on early preclinical biomarkers of atherosclerosis that are unaffected by short-term exposure to air pollution (eg, carotid intima-media thickness [CIMT] and functional performance of the vessel). Air pollution studies using these end points are summarized. The CIMT is currently the most frequently used outcome in this field (6 studies). The continuous nature of CIMT, the lack of short-term variation, its relationship to atherosclerotic changes in the artery wall, its predictive value for coronary heart disease, and the noninvasiveness of the assessment make it a useful candidate for cross-sectional and longitudinal studies investigating the role of air pollution in atherogenesis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Particulate matter; PM(2.5); Atherosclerosis; Cardiovascular diseases; Environment; Endothelial dysfunction; Air quality
Sprache
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 0033-0620
e-ISSN 1532-8643
Zeitschrift Progress in Cardiovascular Diseases
Quellenangaben Band: 53, Heft: 5, Seiten: 334-343 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-504000-001
PubMed ID 21414468
DOI 10.1016/j.pcad.2010.12.006
Scopus ID 79952591759
Erfassungsdatum 2011-08-10
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