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Antonelli, M.C.* ; Frasch, M.G.* ; Rumi, M.* ; Sharma, R. ; Zimmermann, P.* ; Molinet, M.S.* ; Lobmaier, S.M.*

Early biomarkers and intervention programs for the infant exposed to prenatal stress.

Curr. Neuropharmacol. 20, 94-106 (2022)
Verlagsversion Postprint DOI
Open Access Green
Functional development of affective and reward circuits, cognition and response inhibition later in life exhibits vulnerability periods during gestation and early childhood. Extensive evidence supports the model that exposure to stressors in the gestational period and early postnatal life increases an individual's susceptibility to future impairments of functional development. Recent versions of this model integrate epigenetic mechanisms of the developmental response. Their understanding will guide the future treatment of the associated neuropsychiatric disorders. A combination of non-invasively obtainable physiological signals and epigenetic biomarkers related to the principal systems of the stress response, the Hypothalamic-Pituitary axis (HPA) and the Autonomic Nervous System (ANS), are emerging as the key predictors of neurodevelopmental outcomes. Such electrophysiological and epigenetic biomarkers can prove to timely identify children benefiting most from early intervention programs. Such programs should ameliorate future disorders in otherwise healthy children. The recently developed Early Family-Centered Intervention Programs aim to influence the care and stimuli provided daily by the family and improving parent/child attachment, a key element for healthy socio-emotional adult life. Although frequently underestimated, such biomarker-guided early intervention strategy represents a crucial first step in the prevention of future neuropsychiatric problems and in reducing their personal and societal impact.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Maternal Stress ; Epigenetic Biomarkers ; Fhr ; Prsa ; Early Intervention Programs ; Neurodevelopment; Fetal Heart-rate; Maternal Stress; Dna Methylation; Developmental Origins; Glucocorticoid-receptor; Mental-health; Epigenetic Changes; Rate-variability; Gene-expression; Follow-up
ISSN (print) / ISBN 1570-159X
e-ISSN 1875-6190
Zeitschrift Current neuropharmacology
Quellenangaben Band: 20, Heft: 1, Seiten: 94-106 Artikelnummer: , Supplement: ,
Verlag Bentham Science Publishers
Verlagsort San Francisco, Calif.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen Hans Fischer Senior Fellowship from IAS-TUM (Institute for Advanced Study-TUM, Munich, Germany)
Klinik und Poliklinik far Frauenheilkunde, TUM, Klinikum-rechts der Isar, Munich, Germany