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Smith, J.G.* ; Sato, T.* ; Shimaji, K.* ; Koronowski, K.B.* ; Petrus, P.* ; Cervantes, M.* ; Kinouchi, K.* ; Lutter, D. ; Dyar, K.A. ; Sassone-Corsi, P.*

Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain.

Life Sci. 303:120601 (2022)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Circadian ; Gut-brain Axis ; Metabolism ; Microbiome ; Neurometabolism ; Systems Biology
ISSN (print) / ISBN 0024-3205
e-ISSN 1879-0631
Zeitschrift Life Sciences
Quellenangaben Band: 303, Heft: , Seiten: , Artikelnummer: 120601 Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
Institute of Diabetes and Cancer (IDC)