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Kübler, I.C.* ; Kretzschmar, J.* ; Brankatschk, M.* ; Sandoval-Guzmán, T.

Local problems need global solutions - the metabolic needs of regenerating organisms.

Wound Repair Regen. 30, 652-664 (2022)
Postprint DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The vast majority of species that belong to the plant or animal kingdom evolved with two main strategies to counter tissue damage - scar formation and regeneration. Whereas scar formation provides a fast and cost-effective repair to exit life-threatening conditions, complete tissue regeneration is time-consuming and requires vast resources to reinstall functionality of affected organs or structures. Local environments in wound healing are widely studied and findings have provided important biomedical applications. Less well understood are organismic physiological parameters and signaling circuits essential to maintain effective tissue repair. Here, we review accumulated evidence that positions the interplay of local and systemic changes in metabolism as essential variables modulating the injury response. We particularly emphasize the role of lipids and lipid-like molecules as significant components long overlooked.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Insulin ; Lipids ; Metabolism ; Regeneration ; Systemic Response
ISSN (print) / ISBN 1067-1927
e-ISSN 1524-475X
Zeitschrift Wound repair and regeneration
Quellenangaben Band: 30, Heft: 6, Seiten: 652-664 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken, NJ.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Förderungen Medical Research Council, as part ofUK Research and Innovation
Deutsche Forschungsgemeinscha