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Zankl, M. ; Petoussi-Henß, N. ; Janzen, T. ; Uusijärvi, H.* ; Schlattl, H. ; Li, W.B. ; Giussani, A. ; Hoeschen, C.

New calculations for internal dosimetry of beta-emitting radiopharmaceuticals.

Radiat. Prot. Dosim. 139, 245-249 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The calculation of absorbed dose from internally incorporated radionuclides is based on the so-called specific absorbed fractions (SAFs) which represent the fraction of energy emitted in a given source region that is absorbed per unit mass in a specific target organ. Until recently, photon SAFs were calculated using MIRD-type mathematical phantoms. For electrons, the energy released was assumed to be absorbed locally ('ICRP 30 approach'). For this work, photon and electron SAFs were derived with Monte Carlo simulations in the new male voxel-based reference computational phantom adopted by the ICRP and ICRU. The present results show that the assumption of electrons being locally absorbed is not always true at energies above 300-500 keV. For source/target organ pairs in close vicinity, high-energy electrons escaping from the source organ may result in cross-fire electron SAFs in the same order of magnitude as those from photons. Examples of organ absorbed doses per unit activity are given for (18)F-choline and (123)I-iodide. The impact of the new electron SAFs used for absorbed dose calculations compared with the previously used assumptions was found to be small. The organ dose coefficients for the two approaches differ by not more than 6 % for most organs. Only for irradiation of the urinary bladder wall by activity in the contents, the ICRP 30 approach presents an overestimation of approximately 40-50%.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Beta Particles; Body Burden*; Computer Simulation; Humans; Male; Models; Biological*; Radiation Dosage; Radiometry/methods*; Radiopharmaceuticals/analysis*; Radiopharmaceuticals/diagnostic use; Radiopharmaceuticals/pharmacokinetics*; Whole-Body Counting/methods*
Sprache
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Zeitschrift Radiation Protection Dosimetry
Quellenangaben Band: 139, Heft: 1-3, Seiten: 245-249 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Medical Radiation Physics and Diagnostics (AMSD)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-503600-002
G-503600-001
DOI 10.1093/rpd/ncq045
Scopus ID 77953342655
PubMed ID 20167794
Erfassungsdatum 2010-07-28
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