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Engelhard, C.A.* ; Huang, C.* ; Khani, S. ; Kasparek, P.* ; Prochazka, J.* ; Rozman, J.* ; Reguera, D.P.* ; Sedlacek, R.* ; Kornfeld, J.W.*

Comprehensive transcriptional profiling and mouse phenotyping reveals dispensable role for adipose tissue selective long noncoding RNA Gm15551.

Non-coding RNA 8:32 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Cold and nutrient‐activated brown adipose tissue (BAT) is capable of increasing systemic energy expenditure via the uncoupled respiration and secretion of endocrine factors, thereby protecting mice against diet‐induced obesity and improving insulin response and glucose tolerance in men. Long non‐coding RNAs (lncRNAs) have recently been identified as fine‐tuning regulators of cellular function. While certain lncRNAs have been functionally characterised in adipose tissue, their overall contribution in the activation of BAT remains elusive. We identified lncRNAs correlating to interscapular brown adipose tissue (iBAT) function in a high fat diet (HFD) and cold stressed mice. We focused on Gm15551, which has an adipose tissue specific expression profile, is highly upregulated during adipogenesis, and downregulated by β‐adrenergic activation in mature adipocytes. Although we performed comprehensive transcriptional and adipocyte physiology profiling in vitro and in vivo, we could not detect an effect of gain or loss of function of Gm15551.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adipose Tissue Remodelling ; Brown Adipose Tissue ; Long Noncoding Rnas
ISSN (print) / ISBN 2311-553X
e-ISSN 2311-553X
Zeitschrift Non-coding RNA
Quellenangaben Band: 8, Heft: 3, Seiten: , Artikelnummer: 32 Supplement: ,
Verlag MDPI
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen Novo Nordisk Foundation
Danish Diabetes Academy