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Unlocking the barley genome by chromosomal and comparative genomics.
Plant Cell 23, 1249-1263 (2011)
Verlagsversion Volltext
DOI
PMC
We used a novel approach that incorporated chromosome sorting, next-generation sequencing, array hybridization, and systematic exploitation of conserved synteny with model grasses to assign ~86% of the estimated ~32,000 barley (Hordeum vulgare) genes to individual chromosome arms. Using a series of bioinformatically constructed genome zippers that integrate gene indices of rice (Oryza sativa), sorghum (Sorghum bicolor), and Brachypodium distachyon in a conserved synteny model, we were able to assemble 21,766 barley genes in a putative linear order. We show that the barley (H) genome displays a mosaic of structural similarity to hexaploid bread wheat (Triticum aestivum) A, B, and D subgenomes and that orthologous genes in different grasses exhibit signatures of positive selection in different lineages. We present an ordered, information-rich scaffold of the barley genome that provides a valuable and robust framework for the development of novel strategies in cereal breeding.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
pseudo-response-regulator; acetyl-coa carboxylase; triticum-aestivum l.; full-length cdnas; gene-expression; polyploid wheat; 3-phosphoglycerate kinase; phylogenetic analysis; homoeologous group-4; cereal genomics
ISSN (print) / ISBN
1040-4651
e-ISSN
1532-298X
Zeitschrift
The Plant cell
Quellenangaben
Band: 23,
Heft: 4,
Seiten: 1249-1263
Verlag
American Society of Plant Biologists (ASPB)
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed