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Reichart, D.* ; Lindberg, E.L.* ; Maatz, H.* ; Miranda, A.M.A.* ; Viveiros, A.* ; Shvetsov, N.* ; Gärtner, A.* ; Nadelmann, E.R.* ; Lee, M.* ; Kanemaru, K.* ; Ruiz-Orera, J.* ; Strohmenger, V.* ; DeLaughter, D.M.* ; Patone, G.* ; Zhang, H.* ; Woehler, A.* ; Lippert, C.* ; Kim, Y.* ; Adami, E.* ; Gorham, J.M.* ; Barnett, S.N.* ; Brown, K.* ; Buchan, R.J.* ; Chowdhury, R.A.* ; Constantinou, C.* ; Cranley, J.* ; Felkin, L.E.* ; Fox, H.* ; Ghauri, A.* ; Gummert, J.* ; Kanda, M.* ; Li, R.* ; Mach, L.* ; McDonough, B.* ; Samari, S.* ; Shahriaran, F. ; Yapp, C.* ; Stanasiuk, C.* ; Theotokis, P.I.* ; Theis, F.J. ; van den Bogaerdt, A.* ; Wakimoto, H.* ; Ware, J.S.* ; Worth, C.L.* ; Barton, P.J.R.* ; Lee, Y.A.* ; Teichmann, S.A.* ; Milting, H.* ; Noseda, M.* ; Oudit, G.Y.* ; Heinig, M. ; Seidman, J.G.* ; Hubner, N.* ; Seidman, C.E.*

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.

Science 377:eabo1984 (2022)
Postprint DOI PMC
Open Access Green
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) convey high risks for the development of heart failure through unknown mechanisms. Using single-nucleus RNA sequencing, we characterized the transcriptome of 880,000 nuclei from 18 control and 61 failing, nonischemic human hearts with pathogenic variants in DCM and ACM genes or idiopathic disease. We performed genotype-stratified analyses of the ventricular cell lineages and transcriptional states. The resultant DCM and ACM ventricular cell atlas demonstrated distinct right and left ventricular responses, highlighting genotype-associated pathways, intercellular interactions, and differential gene expression at single-cell resolution. Together, these data illuminate both shared and distinct cellular and molecular architectures of human heart failure and suggest candidate therapeutic targets.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 377, Heft: 6606, Seiten: , Artikelnummer: eabo1984 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Förderungen Canadian Institute of Health Research
Howard Hughes Medical Institute
NHLBI NIH HHS