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Bernhardt, D.* ; Grosu, A.* ; Wiestler, B.* ; Rieken, S.* ; Wick, W.* ; Gempt, J.* ; Krieg, S.M.* ; Schmidt-Graf, F.* ; Sahm, F.* ; Meyer, B.* ; Krause, B.J.* ; Petersen, C.* ; Fietkau, R.* ; Thomas, M.A.* ; Giordano, F.A.* ; Wittig-Sauerwein, A.* ; Tabatabai, G.* ; Hau, P.* ; Steinbach, J.* ; Combs, S.E.

DEGRO practical guideline for central nervous system radiation necrosis part 1: Classification and a multistep approach for diagnosis.

Strahlenther. Onkol. 198, 873-883 (2022)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
PURPOSE: The Working Group for Neuro-Oncology of the German Society for Radiation Oncology in cooperation with members of the Neuro-Oncology Working Group of the German Cancer Society aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS). METHODS: Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN including bevacizumab in clinical routine. CONCLUSION: Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neuro-oncologist. A multistep approach as an opportunity to review as many characteristics as possible to improve diagnostic confidence is recommended. Additional information about radiotherapy (RT) techniques is crucial for the diagnosis of RN. Misdiagnosis of untreated and progressive RN can lead to severe neurological deficits. In this practice guideline, we propose a detailed nomenclature of treatment-related changes and a multistep approach for their diagnosis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Bevacizumab ; Brain Metastases ; Glioma ; Radioation Necrosis ; Reirradiation
ISSN (print) / ISBN 0179-7158
e-ISSN 1439-099X
Zeitschrift Strahlentherapie und Onkologie : Journal of Radiation Oncology, Biology, Physics
Quellenangaben Band: 198, Heft: 10, Seiten: 873-883 Artikelnummer: , Supplement: ,
Verlag Urban & Vogel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)