PuSH - Publikationsserver des Helmholtz Zentrums München

Hutzler, C.* ; Luch, A.* ; Filser, J.G.

Analysis of carcinogenic polycyclic aromatic hydrocarbons in complex environmental mixtures by LC-APPI-MS/MS.

Anal. Chim. Acta 702, 218-2224 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Here we developed a highly sensitive, fast and reliable liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the detection and analysis of 16 different polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs that have been identified as carcinogens and classified according to their biological potency. Comparison to standard analysis procedures based on gas chromatography-mass spectrometry (GC-MS) instrumentation demonstrated an improved easiness of sample preparation and sensitivity of detection achieved with the new LC-MS/MS method employing an atmospheric pressure photoionization (APPI) source attached to an API 4000 mass spectrometer (LC-APPI-MS/MS). The favorable outcome could be confirmed by analyzing complex mixtures such as certain Standard Reference Materials (SRMs) obtained from the National Institute of Standards & Technology (NIST), i.e., SRM 1975 and SRM 2975, and several diesel exhaust soots provided by the German automobile industry. Certified concentrations of individual analytes provided by NIST not only could be confirmed, but additional extremely potent carcinogens such as several isomeric hexacyclic dibenzopyrenes (DBPs), 5-methylchrysene (5-MC), and others have been detected in these crude samples in a concentration range down to below 1 ng g(-1) raw material.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter PAHs; Dibenzopyrenes; Dinitropyrenes; LC-APPI-MS/MS; Benzo[a]pyrene; Dibenzo[a,l]pyrene; ATMOSPHERIC-PRESSURE PHOTOIONIZATION; STANDARD REFERENCE MATERIALS; PERFORMANCE LIQUID-CHROMATOGRAPHY; DIESEL PARTICULATE MATTER; TANDEM MASS-SPECTROMETRY; CHEMICAL CARCINOGENESIS; ASSISTED EXTRACTION; MOUSE SKIN; GC-MS; SAMPLES
ISSN (print) / ISBN 0003-2670
e-ISSN 1873-4324
Zeitschrift Analytica Chimica Acta
Quellenangaben Band: 702, Heft: 2, Seiten: 218-2224 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOXI)