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Heine, S. ; Aguilar-Pimentel, J.A. ; Russkamp, D. ; Alessandrini, F. ; Gailus-Durner, V. ; Fuchs, H. ; Ollert, M.* ; Bredehorst, R.* ; Ohnmacht, C. ; Zissler, U.M. ; Hrabě de Angelis, M. ; Schmidt-Weber, C.B. ; Blank, S.

Thermosensitive PLGA-PEG-PLGA hydrogel as depot matrix for allergen-specific immunotherapy.

Pharmaceutics 14:1527 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Allergen-specific immunotherapy (AIT) is the only currently available curative treatment option for allergic diseases. AIT often includes depot-forming and immunostimulatory adjuvants, to prolong allergen presentation and to improve therapeutic efficacy. The use of aluminium salts in AIT, which are commonly used as depot-forming adjuvants, is controversially discussed, due to health concerns and Th2-promoting activity. Therefore, there is the need for novel delivery systems in AIT with similar therapeutic efficacy compared to classical AIT strategies. In this study, a triblock copolymer (hydrogel) was assessed as a delivery system for AIT in a murine model of allergic asthma. We show that the hydrogel combines the advantages of both depot function and biodegradability at the same time. We further demonstrate the suitability of hydrogel to release different bioactive compounds in vitro and in vivo. AIT delivered with hydrogel reduces key parameters of allergic inflammation, such as inflammatory cell infiltration, mucus hypersecretion, and allergen-specific IgE, in a comparable manner to standard AIT treatment. Additionally, hydrogel-based AIT is superior in inducing allergen-specific IgG antibodies with potentially protective functions. Taken together, hydrogel represents a promising delivery system for AIT that is able to combine therapeutic allergen administration with the prolonged release of immunomodulators at the same time.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Allergen-specific Immunotherapy ; Allergic Asthma ; Antigen Release ; Delivery System ; Depot Matrix ; Hydrogel
ISSN (print) / ISBN 1999-4923
e-ISSN 1999-4923
Zeitschrift Pharmaceutics
Quellenangaben Band: 14, Heft: 8, Seiten: , Artikelnummer: 1527 Supplement: ,
Verlag MDPI
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
Institute of Experimental Genetics (IEG)
Förderungen Helmholtz Association of German Research Centres